Erasmus MC : Local Contrast Enhancement for Increased Detection Sensitivity of Early IBD Lesions with MRI

Local Contrast Enhancement for Increased Detection Sensitivity of Early IBD Lesions with MRI

Pagina nog niet beschikbaar in het Nederlands.

Principal Investigator for Radiology: Monique R Bernsen, PhD

The current golden standard for diagnosis and follow-up of inflammatory bowel disease is endoscopy with biopsy. These procedures, however, can cause considerable discomfort to patients. MRI is considered a valuable alternative diagnostic modality without being invasive. Regrettably, MRI performs poorly in detecting early stage lesions in inflammatory bowel disease. Local contrast enhancement at inflammatory sites is thought to improve accuracy of disease assessment by MRI and could be obtained by incorporating MRI contrast agents (Gadolinium) in long circulating liposomes. These liposomes preferentially accumulate at inflammatory sites due to loss of vascular integrity at these sites. In a rat model of inflammatory bowel disease we are developing protocols by which we can assess whether local contrast enhancement using Gadolinium-liposomes indeed improves MRI detection accuracy of early IBD lesions and thus would provide a feasible clinical application (Figure 4). These studies are performed in collaboration with the Erasmus MC Departments of Gastroenterology and Neonatology, the Delft University of Technology, and the Eindhoven University of Technology.

Funding: Erasmus MC Translational Research Seed Grant 2005-2007: "Improved detection accuracy of early IBD lesions with MRI through local contrast enhancement using lipid-based nanocarriers."

Participating researchers Dept. of Radiology: Sandra van Tiel, Remy Geenen, Gabriel Krestin, Piotr Wielopolski, Gavin Houston

Collaborations:

Country	City (State)	Institute	Department	Collaborator
Germany	Munich	GE Medical Systems [ASL Europe]		Timo Schirmer, PhD
the Netherlands	‘s Hertogenbosch	GE Medical Systems [ASL Europe]		Gavin C Houston, PhD
the Netherlands	Delft	Flick Engineering Solutions		Herman Flick, MEng
the Netherlands	Delft	University of Technology	Reactor Instituut	Gerben A Koning, PhD
the Netherlands	Eindhoven	Technical University	Biomedical Engineering	Klaas Nicolay, PhD
the Netherlands	Eindhoven	Technical University	Biomedical Engineering	Gustav J. Strijkers, PhD
the Netherlands	Enschede	University of Twente	Biomedical Optics	Kiran Kumar Thumma
the Netherlands	Rotterdam	Erasmus MC	Cardiology	Heleen MM van Beusekom, PhD
the Netherlands	Rotterdam	Erasmus MC	Cardiology	Ewout Jan van den Bos, MD, PhD
the Netherlands	Rotterdam	Erasmus MC	Cardiology	Dirk J Duncker, MD, PhD
the Netherlands	Rotterdam	Erasmus MC	Cardiology	Wim J van der Giessen, MD, PhD
the Netherlands	Rotterdam	Erasmus MC	Hepatogastroenterology	Ernst J Kuipers, MD, PhD
the Netherlands	Rotterdam	Erasmus MC	Neonatology	Ingrid B Renes, PhD
the Netherlands	Rotterdam	Erasmus MC	Nuclear Medicine	Marion de Jong, PhD
the Netherlands	Rotterdam	Erasmus MC	Orthopedics	Eric J Farrell, PhD
the Netherlands	Rotterdam	Erasmus MC	Orthopedics	Gerjo JVM van Osch, PhD
the Netherlands	Rotterdam	Erasmus MC	Orthopedics	Harrie H Weinans, PhD
the Netherlands	Rotterdam	Erasmus MC	Plastic & Reconstructive Surgery	Ronald I Siphanto, MD
the Netherlands	Rotterdam	Erasmus MC	Surgical Oncology	AMM (Lex) Eggermont, MD, PhD
the Netherlands	Rotterdam	Erasmus MC	Surgical Oncology	Timo LM ten Hagen, PhD
the Netherlands	Rotterdam	Erasmus MC	Surgical Oncology	Gerben A Koning, PhD
the Netherlands	Rotterdam	Erasmus MC	Virology	Fiona Read
the Netherlands	Rotterdam	Erasmus MC	Virology	Thijs Kuiken, DVM, PhD, DACVP
USA	Milwaukee (WI)	GE Medical Systems [ASL Central]		Jason A Polzin, PhD
USA	San Francisco (CA)	University of California	Radiology	Robert C Brasch, MD

Erasmus MC : Local Contrast Enhancement for Increased Detection Sensitivity of Early IBD Lesions with MRI

Doelgroep menu

Local Contrast Enhancement for Increased Detection Sensitivity of Early IBD Lesions with MRI