Multimodality imaging using SPECT, CT and MRI
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Multimodality imaging using SPECT, CT and MRI
Principal Investigator for Radiology: Monique R Bernsen, PhD
Within the department of Nuclear Medicine, radiolabeled receptor binding peptides have been developed as an important class of radiopharmaceuticals for tumor diagnosis and therapy. Further improvements of peptide receptor radionuclide therapy (PRRT) depend on the optimization of radiation doses to tumor versus normal organs. Preclinical high-resolution SPECT and autoradiography studies have indicated that peptide distribution in the tumor is often heterogeneous. By combining microSPECT/CT with MRI we aim at elucidating the influence of tumor (micro-environmental) characteristics on tumor uptake and distribution of radiolabeled peptides and on treatment effects after peptide receptor radionuclide therapy.
Figure 5: Registration of SPECT and MRI
images.
Rigid body matching of (a)
SPECT/CT and SPECT/MRA images and of (b) SPECT/CT and SPECT/DWI images at
the same anatomical position of a tumor implanted in the flank of a
rat.
Participating researchers Dept. of Radiology: Sandra van Tiel, Jifke Veenland, Gavin Houston, Wiro Niessen, Gabriel Krestin, Piotr Wielopolski
Collaborations:
|
Country |
City (State) |
Institute |
Department |
Collaborator |
|
Germany |
Munich |
GE Medical Systems [ASL Europe] |
Timo Schirmer, PhD |
|
|
the Netherlands |
‘s Hertogenbosch |
GE Medical Systems [ASL Europe] |
Gavin C Houston, PhD |
|
|
the Netherlands |
Delft |
Flick Engineering Solutions |
Herman Flick, MEng |
|
|
the Netherlands |
Delft |
University of Technology |
Reactor Instituut |
Gerben A Koning, PhD |
|
the Netherlands |
Eindhoven |
Technical University |
Biomedical Engineering |
Klaas Nicolay, PhD |
|
the Netherlands |
Eindhoven |
Technical University |
Biomedical Engineering |
Gustav J. Strijkers, PhD |
|
the Netherlands |
Enschede |
University of Twente |
Biomedical Optics |
Kiran Kumar Thumma |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Cardiology |
Heleen MM van Beusekom, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Cardiology |
Ewout Jan van den Bos, MD, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Cardiology |
Dirk J Duncker, MD, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Cardiology |
Wim J van der Giessen, MD, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Hepatogastroenterology |
Ernst J Kuipers, MD, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Neonatology |
Ingrid B Renes, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Nuclear Medicine |
Marion de Jong, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Orthopedics |
Eric J Farrell, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Orthopedics |
Gerjo JVM van Osch, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Orthopedics |
Harrie H Weinans, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Plastic & Reconstructive Surgery |
Ronald I Siphanto, MD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Surgical Oncology |
AMM (Lex) Eggermont, MD, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Surgical Oncology |
Timo LM ten Hagen, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Surgical Oncology |
Gerben A Koning, PhD |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Virology |
Fiona Read |
|
the Netherlands |
Rotterdam |
Erasmus MC |
Virology |
Thijs Kuiken, DVM, PhD, DACVP |
|
USA |
Milwaukee (WI) |
GE Medical Systems [ASL Central] |
Jason A Polzin, PhD |
|
|
USA |
San Francisco (CA) |
University of California |
Radiology |
Robert C Brasch, MD |