Hoge Resolutie en Moleculaire Beeldvorming

Informatie over Hoge Resolutie en Moleculaire Beeldvorming

 

Deze informatie is op dit moment alleen beschikbaar in het Engels.

Executive :        Gabriel Krestin, MD, PhD

 

Improvements in the resolution of images is key to progress in radiology.  We are dedicated to improving (clinical) image resolution, especially using MRI and CT.  The research in this area is often directly applied in a clinical trial in one of our Implementation research lines.

Molecular imaging is a rapidly developing field, dedicated to non-invasive, in vivo investigation of molecular and cellular events for biological, diagnostic and therapeutic applications. For optimal exploitation of this field for translational research, close collaboration between basic scientists and clinicians is required.

Within the Erasmus MC Department of Radiology, we have Biologists, an MR physicist, Radiologists and Image Analysis specialists involved in a variety of projects within the Molecular Imaging program.

 

To further enhance the integration of basic science and (potential) clinical applications, we have intensive collaborations with various research groups inside and outside the Erasmus MC.

On a European level, we have set the first steps towards the formation of a consortium focused on all aspects of cellular imaging.

 

Within our molecular imaging program, we not only strive for integration of different disciplines, but also of various imaging modalities. Within Radiology,
clinical 1.5 and 3.0 T MRI scanners and custom-built receiver coils, suitable for micro imaging in whole-body MR systems, and (multi-modality) contrast agents are central to our translational research projects.

 

In addition, The Applied Molecular Imaging at Erasmus MC (AMIE) program is currently realizing an “Animal Imaging Facility” with state-of the-art imaging equipment including a dedicated high-field animal MR scanner. The combination of preclinical research in laboratory animals and top-of-the-line human imaging facilities will advance translational research in molecular medicine.

 

Research lines and projects in the High Resolution and Molecular Imaging sub-program:

 

Cell Tracking by MRI    ( Monique Bernsen)

Optimal labeling strategies

Optimal image acquisition


Optimal analysis and processing

 

In Vivo Application of Labeled Cells (Monique Bernsen)

Stem cell therapy for myocardial infarction

Stem cell therapy for musculoskeletal disorders

 

Local Contrast Enhancement for Increased Detection Sensitivity of Early IBD Lesions with MRI  (Monique Bernsen)

 

 

Multimodality imaging using SPECT, CT and MRI  (Monique Bernsen)

 

 

Assessment of Angiogenesis and Tumor Response: From Microscope to Clinic  ( Kees van Dijke)

Monitoring angiogenesis at microscopic level: A correlative study of  micro-MR imaging and confocal microscopy using labeled contrast agents


MR imaging of chemotherapeutic treatment: Effects on limb-threatening soft tissue tumors

MR imaging of early treatment effects of ILP on sarcomas: Comparing different acquisition protocols

 

High Resolution MRI and Translational Research (Piotr Wielopolski)

MR micro- and molecular imaging: Phased array and parallel imaging technology on whole-body unmodified clinical scanners


High resolution MRI using susceptibility contrast for the detection of vascular structures


High resolution vascular imaging


High resolution imaging for monitoring proliferation and trafficking of magnetically labeled stem cells

High resolution imaging for cartilage and monitoring of cartilage repair therapies

Rodent Cardiac imaging in a clinical platform


MRI of hemorrhage in the heart: Tracking of iron labeled cells


Fiber tracking in healthy and infarcted porcine hearts


High resolution imaging of atherosclerotic plaque