Recent publications

Huang Y, Buscop-van Kempen M, Boerema-de Munck A, Swagemakers S, Driegen S, Meijer D, van IJcken W, van der Spek P, Grosveld F, Tibboel D, Rottier RJ. The hypoxia inducible factor 2α plays a critical role in the formation of alveoli and surfactant. Am. J. Respir. Cell Mol. Biol, 2011

Sluiter I, Reiss I, Kraemer U, de Krijger R, Tibboel D, Rottier RJ. Vascular abnormalities in human newborns with pulmonary hypertension. Expert Rev.Resp.Med. 5(2), 2011

Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Kockx C, van IJcken W, Bezstarosti K, Demmers J, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA. Sox2 cooperates with Chd7 to regulate genes that are mutated in genetically unrelated human syndromes. Nature Genet 2011 43(6):607-11.

Correia-Pinto J, Gonzaga S, Huang Y, Rottier R. Congenital lung lesions--underlying molecular mechanisms. Semin Pediatr Surg. 2010 Aug;19(3):171-9.

Rajatapiti P, de Rooij JD, Beurskens LW, Keijzer R, Tibboel D, Rottier RJ, de Krijger RR. Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants. Neonatology. 2010 Jun;97(4):346-54.

Felix JF, de Jong EM, Torfs CP, de Klein A, Rottier RJ, Tibboel D. Genetic and environmental factors in the etiology of esophageal atresia and/or tracheoesophageal fistula: an overview of the current concepts. Birth Defects Res A Clin Mol Teratol. 2009 Sep;85(9):747-54.

Gontan C, Güttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, Tibboel D, Görlich D, Poot RA, Rottier RJ. Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. J Cell Biol. 2009 Apr 6;185(1):27-34.

Roth S, Franken P, van Veelen W, Blonden L, Raghoebir L, Beverloo B, van Drunen E, Kuipers EJ, Rottier R, Fodde R, Smits R. Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology. Genesis. 2009 Jan;47(1):7-13.

Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R. Sox2 is important for two crucial processes in lung development: branching morphogenesis  and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309.

Rajatapiti P, van der Horst IW, de Rooij JD, Tran MG, Maxwell PH, Tibboel D, Rottier R, de Krijger RR. Expression of hypoxia-inducible factors in normal human lung development. Pediatr Dev Pathol. 2008 May-Jun;11(3):193-9. Epub 2007 Jul 2.

Rajatapiti P, Keijzer R, Blommaart PE, Lamers WH, DE Krijger RR, Visser TJ, Tibboel D, Rottier R. Spatial and temporal expression of glucocorticoid, retinoid, and thyroid hormone receptors is not altered in lungs of congenital diaphragmatic hernia. Pediatr Res. 2006 Dec;60(6):693-8.

Masumoto K, de Rooij JD, Suita S, Rottier R, Tibboel D, de Krijger RR. The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls. Histopathology. 2006 Apr;48(5):588-95.

Masumoto K, de Rooij JD, Suita S, Rottier R, Tibboel D, de Krijger RR. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development. Histopathology. 2005 Oct;47(4):410-9.

Rottier R, Tibboel D. Fetal lung and diaphragm development in congenital diaphragmatic hernia. Semin Perinatol. 2005 Apr;29(2):86-93.

Rajatapiti P, Kester MH, de Krijger RR, Rottier R, Visser TJ, Tibboel D. Expression of glucocorticoid, retinoid, and thyroid hormone receptors during human lung development. J Clin Endocrinol Metab. 2005 Jul;90(7):4309-14.

de Rooij JD, Hösgör M, Ijzendoorn Y, Rottier R, Groenman FA, Tibboel D, de Krijger RR. Expression of angiogenesis-related factors in lungs of patients with congenital diaphragmatic hernia and pulmonary hypoplasia of other causes. Pediatr Dev Pathol. 2004 Sep-Oct;7(5):468-77.

Felix JF, Keijzer R, van Dooren MF, Rottier RJ, Tibboel D. Genetics and developmental biology of oesophageal atresia and tracheo-oesophageal fistula: lessons from mice relevant for paediatric surgeons. Pediatr Surg Int. 2004 Oct;20(10):731-6.

Parera MC, van Dooren M, van Kempen M, de Krijger R, Grosveld F, Tibboel D, Rottier R. Distal angiogenesis: a new concept for lung vascular morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L141-9.