Erasmus MC : Miranda Buitenhuis

After studying Biology at the University of Utrecht, Miranda Buitenhuis (1975) became a PhD student in the Department of Respiratory Medicine at the University Medical Center in Utrecht where she investigated granulocyte development. She did her postdoctoral training in the Department of Immunology at the UMC Utrecht. Here she continued to investigate the molecular mechanisms underlying regulation of cell fate decisions during hematopoiesis. She demonstrated that some signaling molecules only affect proliferation and survival, whereas others are involved in cytokine mediated regulation of lineage choice decisions and maturation. Her results indicate that manipulation of individual molecules could be sufficient to reverse abberantly regulated signal transduction pathways in hematopoietic progenitors from patients with specific hematological malignancies. During her postdoctoral training, she also worked in the Hematopoietic Stem Cell Institute in Lund (2004) and the Laboratory of Stem Cell Therapy in Tokyo (2008) as a guest researcher. From 2007, when she was awarded a VENI grant, research also focused on understanding the cellular and molecular interactions between hematopoietic and mesenchymal stem cells. In September 2009, she relocated to the Department of Hematology in the Erasmus MC, where she started a new research group. Her main goal is to develop novel therapeutic strategies for patients suffering from leukemia by understanding the molecular and cellular mechanisms underlying hematopoietic cell fate decisions within the hematopoietic stem cell niche.

• Bartels et al. (2010) Haematologica in press
• Buitenhuis et al. (2009) Cell Cycle 8(4):560-6
• Geest et al. (2009) Blood 114(16):3402-12
• Geest et al. (2009) Haematologica 94(7):901-10
• Geest et al. (2009) Stem Cells 27(9):2271-82
• Geest et al. (2009) Haematologica 94(8):1075-84
• Buitenhuis et al. (2008) Blood 111(1):112-21
• Ulfman et al. (2008) J Immunol 180(8):5512-9
• Buitenhuis et al. (2007) Cancer Research  67(8):3759-66
• Rijkers et al. (2007) Eur J Haematol 79 (5), 410–6
• Castor et al. (2005) ) Nat Med. 11(6): 630-7
• Buitenhuis et al. (2005) Blood. 105(11): 4272-81
• Buitenhuis et al. (2004) Int J Biochem Cell Biol 36(11): 2120-4
• Buitenhuis et al. (2003) Blood . 101(1): 134-42
• Baltus et al. (1999) . J Leukoc Biol 66:683-8
• Caldenhoven et al. (1999) J Leukoc Biol 65 (3): 391-6