Erasmus MC : Ricardo Fodde

Riccardo Fodde studied biology and molecular genetics at the University of Pavia, Italy. His PhD work on hemoglobins and haptoglobins has been carried out at the Dept. of Human Genetics of the University of Leiden, and has led to the characterization of the spectrum of mutations leading to hemoglobinopathies in The Netherlands. In 1990 he started his post-doctoral work on the molecular genetic basis of colorectal cancer within the same department. As a fellow of the Royal Dutch Academy of Science (KNAW) he visited the laboratory of Prof. Raju Kucherlapati at the A. Einstein College of Medicine in New York, where he developed the first targeted mouse model for intestinal tumorigenesis. In 2001, he became full professor of Cancer Genetics at the Center for Human & Clinical Genetics of the Leiden University Medical Center (LUMC). His group has contributed to the elucidation of the molecular basis of hereditary colorectal cancer in man, developed a large number of pre-clinical mouse models for colorectal carcinogenesis, and characterized novel functional aspects of the APC tumor suppressor gene. Most recently, the focus of his research has been centered around the role of Wnt/-catenin signaling in embryonic and stem cell differentiation and in the onset of cancer stemness. Also, based on the recent identification of the hitherto elusive quiescent stem cell of the intestinal epithelium, his research is now focusing on the role of these cells in inflammation and cancer. In 2002 he became an elected member of EMBO. Since 2003 he is Professor of Experimental Pathology at the Josephine Nefkens Institute of the Erasmus Medical Center in Rotterdam.

• Fodde et al.(2001) Nat Rev Cancer 1:55-67
• Fodde et al. (2001) Nat Cell Biol 3:433-8
• Kielman, et al.(2002) Nat Genet 32:594-605
• Janssen et al. (2006) Gastroenterology 13:1096-1109
• Cardoso et al.(2006) Cancer Res 66:2514-2519
• Alberici et al. (2007) Am J Pathol 170:377-387
• Fodde & Brabletz (2007) Curr Opin Cell Biol 19:50-158
• Siddappa et al.(2008) Proc Natl Acad Sci USA 105(20):7281-6
• Burn et al. (2008) N Engl J Med 359:2567-2578
• Roth et al. (2009) Genesis  47(1):7-13
• Alberici et al. (2008) Pathogenetics 1(1):2
• Burn et al.(2008) N Engl J Med 259(24):2567-78
• Fodde (2009) Cancer Cell 15(2):87-9
• Miclea et al.(2009) BMC Dev Biol. 8;9:26
• Gaspar et al.(2009) PLoS Genet 5(7):e1000547
• Wang et al. (2009) Clin Cancer Res 15(18)5784-93