Erasmus MC : Joost Gribnau

Joost Gribnau studied biology at the University of Leiden and received his PhD in Molecular Biology from the Erasmus University Rotterdam. Here he studied the role of intergenic transcription in globin gene regulation. He did his postdoctoral training at the Whitehead Institute for Biomedical Research (MIT), and studied factors involved in genomic imprinting and X chromosome inactivation. In 2005 he moved to the Erasmus Medical Center (Rotterdam) starting his own research group and continued his interest in the X chromosome inactivation process. His research group discovered that X chromosome inactivation is a stochastic process, and has recently identified the first X-encoded trans-acting factor involved in activation of the X chromosome inactivation process. He received several awards including a Career Development Award from the Human Frontiers Science Organization, and NWO VIDI and VICI awards. He currently holds a position as Associate Professor at the Department of Reproduction and Development at the Erasmus Medical Center, and aims to further understand the X inactivation process, using embryonic stem cells as a model system.

• Gribnau et al. (2000) Mol Cell 5:377-386
  Biniszkiewicz et al. (2002) Mol Cell Biol 22:2124-2135
  Gribnau et al. (2003) Genes Dev 17:759-773
  Singh et al. (2003) Nat Genet 33:339-341
  Geijsen et al. (2004) Nature 427:148-154
  Gribnau et al. (2005) J Cell Biol 365-373
  Mlynarczyk-Evans (2006) PLoS Biol 4:159-171
  Monkhorst et al. (2008) Cell 132:410-421
  Jonkers et al. (2008) Mol Cell Biol 28:5583-5594
  Heath et al.(2008) EMBO J  27(21):2839-50
  Monkhorst et al (2009) PLoS One 45):e5616
  Van den Berg et al.(2009) Am J Hum Genet 84 (6):771-9
  Jonkers et al. (2009) Cell 139(5):999-1011
  Barakat et al. (2010) Exp Cell Res