Grosveld, Frank
Frank Grosveld studied biochemistry at the University of Amsterdam and obtained a PhD from McGill University (1976). After two postdoctoral periods (Zurich, C. Weissmann and London, R. Flavell), he became Head of the division (1981) of Gene Structure and Expression at the National Institute for Medical Research, Mill Hill, UK. In 1993 he accepted the Chair of Cell Biology at the Erasmus University Rotterdam. Mechanisms of gene regulation and epigenetic phenomena have been the primary focus of his research.
His group has carried out pioneering work in many aspects of gene regulation from concluding that DNA methylation inhibits gene expression via an indirect mechanism, to the first description of an LCR, visualizing the primary transcription process in the nucleus and most recently the decription of 3D interactions in the nucleus. His group has filed a considerable number of patents and has closely collaborated with industrial partners.
He is chairman of the Research School MGC and board member of the top research school CBG. He is and has been on the advisory board of research councils, institutes and companies and is co-founder of four companies. He was recently appointed as an Academy Professor of the Ryal Academy of Sciences NL.
Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J (2005)
GATA-1 forms distinct activating and repressive complexes in erythroid cells
EMBO J 6;24(13):2354-66
Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, Gering M, Patient R, Hostert A, Grosveld F (2006)
Novel binding partners of Ldb1 are required for haematopoietic development
Development 133(24):4913-23
Jhunjhunwala S, van Zelm MC, Peak MM, Cutchin S, Riblet R, van Dongen JJ, Grosveld FG, Knoch TA, Murre C (2008)
The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions
Cell 133:265-79
de Laat W, Klous P, Kooren J, Noordermeer D, Palstra RJ, Simonis M, Splinter E, Grosveld F (2008)
Three-dimensional organization of gene expression in erythroid cells
Curr Top Dev Biol 82:117-39
Monkhorst K, Jonkers I, Rentmeester E, Grosveld F, Gribnau J (2008)
X inactivation counting and choice is a stochastic process: evidence for involvement of an X-linked activator
Cell 132:410-421