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Grosveld, Frank

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Frank Grosveld studied biochemistry at the University of Amsterdam and obtained a PhD from McGill University (1976). After two postdoctoral periods (Zurich, C. Weissmann and London, R. Flavell), he became Head of the division (1981) of Gene Structure and Expression at the National Institute for Medical Research, Mill Hill, UK. In 1993 he accepted the Chair of Cell Biology at the Erasmus University Rotterdam. Mechanisms of gene regulation and epigenetic phenomena have been the primary focus of his research.

His group has carried out pioneering work in many aspects of gene regulation from concluding that DNA methylation inhibits gene expression via an indirect mechanism, to the first description of an LCR, visualizing the primary transcription process in the nucleus and most recently the decription of 3D interactions in the nucleus. His group has filed a considerable number of patents and has closely collaborated with industrial partners.

He is chairman of the Research School MGC. He is and has been on the advisory board of research councils, institutes and companies and is co-founder of four companies. In 2008, he was appointed as Academy Professor of the Royal Netherlands Academy of Arts and Science. In 2013, Frank Grosveld received knighthood in the Order of the Netherlands Lion. 

Department of Cell Biology website

 

Selected publications

Mylona M, Andrieu-Soler C, Thongjuea S, Martella A, Soler E, Jorna R, Hou J, Kockx C, van IJcken W, Lenhard B and Grosveld F (2013)
Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis
Blood 121:2902-2913
 
Ghamari A, van de Corput M, Thongjuea S, van Cappellen W, van Ijcken W, van Haren J, Soler E, Eick D, Lenhard B and Grosveld F (2013)
In vivo live imaging of RNA polymerase II transcription factories in primary mouse cells
Genes and Dev 27:767–777

Eric Soler, Charlotte Andrieu-Soler, Ernie de Boer, Jan Christian Bryne, Supat Thongjuea, Ralph Stadhouders, Robert-Jan Palstra, Christel Kockx, Wilfred van IJcken, Jun Hou, Christine Steinhoff, Erikjan Rijkers, Boris Lenhard and Frank Grosveld (2010)
The Genome Wide Dynamics of the Binding of the Ldb1 Complex during Erythroid Differentiation
Genes Dev 24:277-289

Stadhouders R, Thongjuea S, Andrieu-Soler C, Palstra RJ, Bryne JC, van den Heuvel A, Stevens M, de Boer E, Kockx C, van der Sloot A, van den Hout M, van Ijcken W, Eick D, Lenhard B, Grosveld F, Soler E (2011)
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development
EMBO J 31(4):986-99

Kolovos P, Knoch TA, Grosveld FG, Cook PR, Papantonis A (2012)
Enhancers and silencers: an integrated and simple model for their function
Epigenetics Chromatin 5(1):1