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Publications

Recent publications

Gutierrez, L., Tsukamoto, S., Suzuki, M., Yamamoto-Mukai, H., Yamamoto, M., Philipsen, S., Ohneda, K. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Blood. 2008 111: 4375-85.
PubMed: 18258797

Chan, P. K., Wai, A., Philipsen, S., Tan-Un, K. C. 5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub. PLoS ONE. 2008 3: e2134.
PubMed: 18461170

van Loo, P. F., Mahtab, E. A., Wisse, L. J., Hou, J., Grosveld, F., Suske, G., Philipsen, S., Gittenberger-de Groot, A. C. Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007 27: 8571-82.
PubMed: 17923686

Kruger, I., Vollmer, M., Simmons, D. G., Elsasser, H. P., Philipsen, S., Suske, G. Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects. Dev Dyn. 2007 236: 2235-44.
PubMed: 17584888

Gutierrez, L., Nikolic, T., van Dijk, T. B., Hammad, H., Vos, N., Willart, M., Grosveld, F., Philipsen, S., Lambrecht, B. N. Gata1 regulates dendritic-cell development and survival. Blood. 2007 110: 1933-41.
PubMed: 17505015

Guo, X., Philipsen, S., Tan-Un, K. C. Study of the hypoxia-dependent regulation of human CYGB gene. Biochem Biophys Res Commun. 2007 364: 145-50.
PubMed: 17936249

Ferreira, R., Wai, A., Shimizu, R., Gillemans, N., Rottier, R., von Lindern, M., Ohneda, K., Grosveld, F., Yamamoto, M., Philipsen, S. Dynamic regulation of Gata factor levels is more important than their identity. Blood. 2007 109: 5481-90.
PubMed: 17327407

Chan, P. K., Ma, E. S., Philipsen, S., Tan-Un, K. C. The study of sequence configuration and functional impact of the (AC)n(AT)xTy motif in human beta-globin gene promoter. Am J Hematol. 2007 82: 342-8.
PubMed: 17133428

Suzuki, M., Ohneda, K., Hosoya-Ohmura, S., Tsukamoto, S., Ohneda, O., Philipsen, S., Yamamoto, M. Real-time monitoring of stress erythropoiesis in vivo using Gata1 and beta-globin LCR luciferase transgenic mice. Blood. 2006 108: 726-33.
PubMed: 16537808

Rodriguez, P., Braun, H., Kolodziej, K. E., de Boer, E., Campbell, J., Bonte, E., Grosveld, F., Philipsen, S., Strouboulis, J. Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads. Methods Mol Biol. 2006 338: 305-23.
PubMed: 16888367

Migliaccio, A. R., Philipsen, S. Reflections on the European Union Eurythron Network Meeting "Molecular Control of Erythropoiesis," September 22-23, 2005, Istituto Superiore di Sanita, Rome, Italy. Stem Cells. 2006 24: 2478-82.
PubMed: 16960127

Migliaccio, A. R., Philipsen, S. The return of Romeo. Scientists' international mobility and the future of research in Europe. EMBO Rep. 2006 7: 1067-71.
PubMed: 17077860

Guo, X., Philipsen, S., Tan-Un, K. C. Characterization of human cytoglobin gene promoter region. Biochim Biophys Acta. 2006 1759: 208-15.
PubMed: 16797742

Suske, G., Bruford, E., Philipsen, S. Mammalian SP/KLF transcription factors: bring in the family. Genomics. 2005 85: 551-6.
PubMed: 15820306

Pan, X., Ohneda, O., Ohneda, K., Lindeboom, F., Iwata, F., Shimizu, R., Nagano, M., Suwabe, N., Philipsen, S., Lim, K. C., Engel, J. D., Yamamoto, M. Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors. J Biol Chem. 2005 280: 22385-94.
PubMed: 15817467

Gutierrez, L., Lindeboom, F., Ferreira, R., Drissen, R., Grosveld, F., Whyatt, D., Philipsen, S. A hanging drop culture method to study terminal erythroid differentiation. Exp Hematol. 2005 33: 1083-91.
PubMed: 16219530

Ferreira, R., Ohneda, K., Yamamoto, M., Philipsen, S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol. 2005 25: 1215-27.
PubMed: 15684376

Drissen, R., von Lindern, M., Kolbus, A., Driegen, S., Steinlein, P., Beug, H., Grosveld, F., Philipsen, S. The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol. 2005 25: 5205-14.
PubMed: 15923635

Driegen, S., Ferreira, R., van Zon, A., Strouboulis, J., Jaegle, M., Grosveld, F., Philipsen, S., Meijer, D. A generic tool for biotinylation of tagged proteins in transgenic mice. Transgenic Res. 2005 14: 477-82.
PubMed: 16201414

Shimizu, R., Kuroha, T., Ohneda, O., Pan, X., Ohneda, K., Takahashi, S., Philipsen, S., Yamamoto, M. Leukemogenesis caused by incapacitated GATA-1 function. Mol Cell Biol. 2004 24: 10814-25.
PubMed: 15572684

Gutierrez, L., Lindeboom, F., Langeveld, A., Grosveld, F., Philipsen, S., Whyatt, D. Homotypic signalling regulates Gata1 activity in the erythroblastic island. Development. 2004 131: 3183-93.
PubMed: 15175249

Drissen, R., Palstra, R. J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S., de Laat, W. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 2004 18: 2485-90.
PubMed: 15489291

Christensen, M. A., Zhou, W., Qing, H., Lehman, A., Philipsen, S., Song, W. Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol Cell Biol. 2004 24: 865-74.
PubMed: 14701757

Wai, A. W., Gillemans, N., Raguz-Bolognesi, S., Pruzina, S., Zafarana, G., Meijer, D., Philipsen, S., Grosveld, F. HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells. Embo J. 2003 22: 4489-500.
PubMed: 12941700

Van Loo, P. F., Bouwman, P., Ling, K. W., Middendorp, S., Suske, G., Grosveld, F., Dzierzak, E., Philipsen, S., Hendriks, R. W. Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood. 2003 102: 858-66.
PubMed: 12676787

Lindeboom, F., Gillemans, N., Karis, A., Jaegle, M., Meijer, D., Grosveld, F., Philipsen, S. A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Res. 2003 31: 5405-12.
PubMed: 12954777

Gillemans, N., McMorrow, T., Tewari, R., Wai, A. W., Burgtorf, C., Drabek, D., Ventress, N., Langeveld, A., Higgs, D., Tan-Un, K., Grosveld, F., Philipsen, S. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 2003 101: 2842-9.
PubMed: 12517812

Bouwman, P., Philipsen, S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol. 2002 195: 27-38.
PubMed: 12354670