Publications
Recent publications
Gutierrez, L., Tsukamoto, S., Suzuki, M., Yamamoto-Mukai, H., Yamamoto, M., Philipsen, S., Ohneda, K. Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis. Blood. 2008 111: 4375-85.
PubMed: 18258797
Chan, P. K., Wai, A., Philipsen, S., Tan-Un, K. C. 5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub. PLoS ONE. 2008 3: e2134.
PubMed: 18461170
van Loo, P. F., Mahtab, E. A., Wisse, L. J., Hou, J., Grosveld, F., Suske, G., Philipsen, S., Gittenberger-de Groot, A. C. Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007 27: 8571-82.
PubMed: 17923686
Kruger, I., Vollmer, M., Simmons, D. G., Elsasser, H. P., Philipsen, S., Suske, G. Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects. Dev Dyn. 2007 236: 2235-44.
PubMed: 17584888
Gutierrez, L., Nikolic, T., van Dijk, T. B., Hammad, H., Vos, N., Willart, M., Grosveld, F., Philipsen, S., Lambrecht, B. N. Gata1 regulates dendritic-cell development and survival. Blood. 2007 110: 1933-41.
PubMed: 17505015
Guo, X., Philipsen, S., Tan-Un, K. C. Study of the hypoxia-dependent regulation of human CYGB gene. Biochem Biophys Res Commun. 2007 364: 145-50.
PubMed: 17936249
Ferreira, R., Wai, A., Shimizu, R., Gillemans, N., Rottier, R., von Lindern, M., Ohneda, K., Grosveld, F., Yamamoto, M., Philipsen, S. Dynamic regulation of Gata factor levels is more important than their identity. Blood. 2007 109: 5481-90.
PubMed: 17327407
Chan, P. K., Ma, E. S., Philipsen, S., Tan-Un, K. C. The study of sequence configuration and functional impact of the (AC)n(AT)xTy motif in human beta-globin gene promoter. Am J Hematol. 2007 82: 342-8.
PubMed: 17133428
Suzuki, M., Ohneda, K., Hosoya-Ohmura, S., Tsukamoto, S., Ohneda, O., Philipsen, S., Yamamoto, M. Real-time monitoring of stress erythropoiesis in vivo using Gata1 and beta-globin LCR luciferase transgenic mice. Blood. 2006 108: 726-33.
PubMed: 16537808
Rodriguez, P., Braun, H., Kolodziej, K. E., de Boer, E., Campbell, J., Bonte, E., Grosveld, F., Philipsen, S., Strouboulis, J. Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads. Methods Mol Biol. 2006 338: 305-23.
PubMed: 16888367
Migliaccio, A. R., Philipsen, S. Reflections on the European Union Eurythron Network Meeting "Molecular Control of Erythropoiesis," September 22-23, 2005, Istituto Superiore di Sanita, Rome, Italy. Stem Cells. 2006 24: 2478-82.
PubMed: 16960127
Migliaccio, A. R., Philipsen, S. The return of Romeo. Scientists' international mobility and the future of research in Europe. EMBO Rep. 2006 7: 1067-71.
PubMed: 17077860
Guo, X., Philipsen, S., Tan-Un, K. C. Characterization of human cytoglobin gene promoter region. Biochim Biophys Acta. 2006 1759: 208-15.
PubMed: 16797742
Suske, G., Bruford, E., Philipsen, S. Mammalian SP/KLF transcription factors: bring in the family. Genomics. 2005 85: 551-6.
PubMed: 15820306
Pan, X., Ohneda, O., Ohneda, K., Lindeboom, F., Iwata, F., Shimizu, R., Nagano, M., Suwabe, N., Philipsen, S., Lim, K. C., Engel, J. D., Yamamoto, M. Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors. J Biol Chem. 2005 280: 22385-94.
PubMed: 15817467
Gutierrez, L., Lindeboom, F., Ferreira, R., Drissen, R., Grosveld, F., Whyatt, D., Philipsen, S. A hanging drop culture method to study terminal erythroid differentiation. Exp Hematol. 2005 33: 1083-91.
PubMed: 16219530
Ferreira, R., Ohneda, K., Yamamoto, M., Philipsen, S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol. 2005 25: 1215-27.
PubMed: 15684376
Drissen, R., von Lindern, M., Kolbus, A., Driegen, S., Steinlein, P., Beug, H., Grosveld, F., Philipsen, S. The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol. 2005 25: 5205-14.
PubMed: 15923635
Driegen, S., Ferreira, R., van Zon, A., Strouboulis, J., Jaegle, M., Grosveld, F., Philipsen, S., Meijer, D. A generic tool for biotinylation of tagged proteins in transgenic mice. Transgenic Res. 2005 14: 477-82.
PubMed: 16201414
Shimizu, R., Kuroha, T., Ohneda, O., Pan, X., Ohneda, K., Takahashi, S., Philipsen, S., Yamamoto, M. Leukemogenesis caused by incapacitated GATA-1 function. Mol Cell Biol. 2004 24: 10814-25.
PubMed: 15572684
Gutierrez, L., Lindeboom, F., Langeveld, A., Grosveld, F., Philipsen, S., Whyatt, D. Homotypic signalling regulates Gata1 activity in the erythroblastic island. Development. 2004 131: 3183-93.
PubMed: 15175249
Drissen, R., Palstra, R. J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S., de Laat, W. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 2004 18: 2485-90.
PubMed: 15489291
Christensen, M. A., Zhou, W., Qing, H., Lehman, A., Philipsen, S., Song, W. Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol Cell Biol. 2004 24: 865-74.
PubMed: 14701757
Wai, A. W., Gillemans, N., Raguz-Bolognesi, S., Pruzina, S., Zafarana, G., Meijer, D., Philipsen, S., Grosveld, F. HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells. Embo J. 2003 22: 4489-500.
PubMed: 12941700
Van Loo, P. F., Bouwman, P., Ling, K. W., Middendorp, S., Suske, G., Grosveld, F., Dzierzak, E., Philipsen, S., Hendriks, R. W. Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood. 2003 102: 858-66.
PubMed: 12676787
Lindeboom, F., Gillemans, N., Karis, A., Jaegle, M., Meijer, D., Grosveld, F., Philipsen, S. A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Res. 2003 31: 5405-12.
PubMed: 12954777
Gillemans, N., McMorrow, T., Tewari, R., Wai, A. W., Burgtorf, C., Drabek, D., Ventress, N., Langeveld, A., Higgs, D., Tan-Un, K., Grosveld, F., Philipsen, S. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 2003 101: 2842-9.
PubMed: 12517812
Bouwman, P., Philipsen, S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol. 2002 195: 27-38.
PubMed: 12354670