Projecten
een overzicht van recente onderzoeksprojecten
programme no. EMC 04-28-01
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core programme 3 |
Immunology and Hematology |
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subcluster 3.2 |
Infectious diseases: micro-organisms & host response |
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programme title |
Infections due to bacteria, fungi and parasites: diagnosis, molecular mechanisms, epidemiology, therapy and prevention |
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main participants |
Verbrugh Prof. Dr. H.A., Bakker-Woudenberg Mw. Dr. I.A.J.M., Van Belkum Prof. Dr. A., Endtz Dr. H.Ph. |
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key words |
Prevention of (Nosocomial) infection, Epidemiology, Diagnosis, Therapy, Pathogenicity. |
general objectives
The project is focused on the infectious complications caused by bacteria, fungi and parasites related to recent developments in clinical medicine, such as new therapeutic modalities or resistance, an increased use of medical devices, frequent diagnostic and therapeutic intervention, and an increasing number of immunocompromised patients. As a consequence, a growing number of patients are prone to severe (nosocomial) infections that are often difficult to treat. These infections are a major cause of morbidity and mortality in these patients, which is partially enforced by failure of antibiotic treatment despite the availability of potent antibiotics. The focus of this programme is on the molecular mechanism of infection, the epidemiology, the early diagnosis using molecular techniques, the prevention of infections, as well as treatment using alternative methods. The approach is partly fundamental/animal-experimental and partly clinical/epidemiological .
overzicht lopende projecten
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Post-infectious sequelae of Campylobacter jejuni diarrhea | |
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multidisciplinary project (involving Erasmus MC Immunology and Neurology departments) focussing on the etiology of the Guillain Barré Syndrome as induced by preceding C. jejuni diarrhea | |
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bezetting |
1 .6fte research technician, 2 PhD students, 1fte postdoc |
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projectleider(s) |
dr. H.P. Endtz, prof.dr. A. van Belkum |
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extramurale financiering |
Frontier Science Project RGP 38/2003 (Molecular basis and neurobiology of a post-infectious auto-immune disease: the Guillain-Barré Syndrome) $330.000,--; ended 15 november 2006. Per 1 november 2006 a project sponsored by the Dutch Maag Lever Darm Stichting has been started (110.000,-- financial support, duration three years). |
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interne samenwerking |
dr. B. Jacobs, Neurology; prof.dr. P. van Doorn, Neurology; prof.dr. J. Laman, Immunology. |
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externe samenwerking |
prof.dr. P. Crocker, Cell Biology, Edinburgh, UK; dr. M. Gilbert, NRC, Ottawa, Canada; dr. G. Visser, Organic Chemistry, Wageningen, The Netherlands; dr. J. van der Vossen, TNO Voeding, Zeist, The Netherlands; dr. N. Yuki, Neurology, Dokkyo, Japan; dr. H. Zuilhof, Physical Chemistry, Wageningen, The Netherlands |
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Clinical and epidemiological implications of nasal carriage of Staphylococcus aureus | |
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major research project of the department, focussing on epidemiology, prevention, determinants and molecular microbiology of S. aureus carriage | |
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bezetting |
2.0fte research technician, 1 PhD student, 1fte postdoc |
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projectleider(s) |
prof.dr. A. van Belkum, prof.dr. H.A. Verbrugh |
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extramurale financiering |
Revolving Fund Erasmus MC (Development and application of methods suited for high-speed diagnosis of nasal carriage of (methicicllin resistant) Staphylococcus aureus) €50.000,-- research support. EUR Trustfund (Nasal carriage of Staphylococcus aureus: inoculation of site directed mutants in the noses of (non)carrying volunteers) €30.000,- research support |
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interne samenwerking |
dr. M. Fieren, Nephrology; prof.dr. A. Hofman, Epidemiology; dr. J. Peeters, Bioinformatics; prof.dr. P. van der Spek, Bioinformatics; dr. A. Uitterlinden, Internal Medicine |
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externe samenwerking |
dr. M. Al Ahdal, KFHRC, Riyadh, Saudi Arabia; dr. W. Al Aidan, KFHRC, Riyadh, Saudi Arabia; dr. J. Johnson, VAMC, Minneapolis, USA; dr. J. Kluytmans, Breda, The Netherlands; dr. P. Savelkoul, VUMC, Amsterdam, The Netherlands; dr. G. Simons, Pathofinder, Maastricht, The Netherlands; prof.dr. C. Vandebroucke-Grauls, VUMC, Amsterdam, The Netherlands |
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Etiology and epidemiology of infections caused by the madura foot causing agent Madurella mycetomatis | |
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collaboration with the Madura Clinic in Khartoum, Sudan; involves a single PhD student working on the etiology, diagnosis, epidemiology, prevention and cure of this devastating disease | |
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bezetting |
1 PhD student |
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projectleider(s) |
prof.dr. A. van Belkum |
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extramurale financiering |
none |
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externe samenwerking |
dr. A. Ahmed, KFHRC, Riyadh, Saudi Arabia; prof.dr. A. Fahal, University of Khartoum, Sudan |
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The use of Raman spectroscopy for subspecies identification of bacterial isolates | |
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collaboration between the Center for Optical Diagnostics and Therapy and the Dept. Microbiology, geared towards the development of Raman tools for epidemiological monitoring of bacterial isolates and the development of real-time diagnostic microbiological assays | |
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bezetting |
1fte research technician |
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projectleider(s) |
dr. G. Puppels, dr. H.P. Endtz, prof.dr. A. van Belkum |
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extramurale financiering |
STW project Raman spectroscopy in medical microbiology (1fte technician for four years) |
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interne samenwerking |
dr. K. Maquelin en dr. G. Puppels, Center for Optical Diagnosis and Therapy (CODT) |
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externe samenwerking |
dr. P. Petit, MCRZ, Rotterdam, The Netherlands |
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Innovation of molecular diagnostics within medical microbiology | |
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multiplex Ligation Probe Assays (MLPA) facilitate high-speed and sensitive detection of panels of microbial pathogens, a PhD student is working on the clinical implementation of high-throughput real time PCR tests in the microbiology laboratory | |
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bezetting |
1 PhD student , 1fte research technician |
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projectleider(s) |
dr. G. Simons, dr. W. van Leeuwen, prof.dr. A. van Belkum |
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extramurale financiering |
BTS (MLPA as a new method for the high speed diagnosis of infectious agents) €120.000,- research support |
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externe samenwerking |
prof.dr. M.-Mikolajczyk, Medical Academy, Warsaw, Poland; dr. P. Oostvogel, MCH, Den Haag, The Netherlands; dr. H. Pituch, Medical Academy, Warsaw, Poland; prof.dr. J. Schrenzel, Basel, Zwitserland; ing. T. Schuurman, Streeklab, Groningen, The Netherlands; dr. G. Simons, Pathofinder, Maastricht, The Netherlands |
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Development of eradication methods for Moraxella catarrhalis, a major cause of otitis media in children | |
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project that was finished December 2005, a single PhD student worked on this topic for the past four years, a successful collaboration with the local department of Pediatrics was established | |
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bezetting |
J.P. Hays |
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projectleider(s) |
prof.dr. A. van Belkum |
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extramurale financiering |
has been sponsored for two years by the Sophia Research Foundation |
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interne samenwerking |
dr. J. Hazelzet, Pediatric IC |
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externe samenwerking |
dr. P. Hermans, Lab Pediatrics, Nijmegen, The Netherlands; prof.dr. J. Tommassen, RUU, Utrecht, The Netherlands |
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Novel Prevention and Treatment Strategies for Otitis Media through the Comprehensive Identification of Antigenic Proteins. | |
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bezetting |
dr. J.P. Hays, S. Verhaegh (OIO) |
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projectleider(s) |
prof. dr. A. van Belkum, dr. J.P. Hays |
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extramurale financiering |
EU-funded FP6 project. Project No. – 037653 (OMVac). € 355,000 |
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interne samenwerking |
Intercell AG, Vienna, Austria AGOWA AG, Berlin, Germany |
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externe samenwerking |
prof. dr. P. Hermans, RUNMC, Niujmegen, The Netherlands prof. dr. B. Henriques-Normark, Karolinska Institutet, Stockholm, Sweden dr. E. Ban, Semmelweis University, Budapest, Hungary dr. A. Kungl, KF-University Graz, Graz, Austria. |
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Role of Mobile Genetic Elements in the Spread of Antimicrobial Drug Resistance | |
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bezetting |
dr. J.P. Hays, M.A. Khan. (OIO) |
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projectleider(s) |
prof.dr. A. van Belkum |
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extramurale financiering |
EU-funded FP6 project. Project No. – 018705 (DRESP2). € 175,000 |
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interne samenwerking |
prof. dr. M. R. Oggioni, Università di Siena, Siena, Italy dr. D. J. Farrell, GR Micro Ltd, UK prof. dr. S. Stefani, Università di Catania, Catania, Italy prof. dr. F. Baquero, Ramón y Cajal , Madrid, Spain |
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externe samenwerking |
dr. L. Sundström, Uppsala Universitet, Uppsala, Sweden prof. dr. A. Carattoli, Istituto Superiore di Sanità (ISS), Rome, Italy prof. dr. P. Nordmann, University Paris XI, Paris, France dr. J-L Martínez, Centro Nacional de Biotecnología, Madrid, Spain prof. dr. T. Walsh, Cardiff University, Cardiff, UK dr. B. Libisch, Natl. Center Epidemiology, Budapest, Hungary |
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Pathogenesis, diagnostics and treatment of Invasive Pulmonary Aspergillosis in the immunocompromised host, in vitro studies and animal studies. | |
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bezetting |
W. van de Sande, M. Tavakol (deels), M. T. ten Kate (deels) |
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projectleider(s) |
dr. I.A.J.M. Bakker, prof. dr. A. van Belkum |
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extramurale financiering |
has been sponsored by Merck Sharp & Dohme B.V. € 64.701,--, and Pfizer B.V. € 94.765,-- |
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interne samenwerking |
dr. B. Rijnders, dept. MMIZ; dr. R.A. Mathot, Hospital Pharmacy EMC |
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externe samenwerking |
dr. C. Douglas, dr. J. Bowman, Merck Research Laboratories, Rahway, NJ, USA |
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Beta-lactam resistance in Gram-negative bacteria: relevance of pharmacokinetics/pharmacodynamics in the selection of resistance, resistance mechanisms and prevention of resistance during treatment, in vitro studies and animal studies | |
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bezetting |
M. T. ten Kate (deels), N. Lemmens (deels) |
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projectleider(s) |
dr. W.H.F. Goessens, dr. I.A.J.M. Bakker |
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extramurale financiering |
ESCMID / AstraZeneca Research Grant € 40.000,-- |
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externe samenwerking |
dr. J.W. Mouton, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands |
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Therapy of tuberculosis: drug delivery to reduce treatment duration with prevention of resistance and latency, relevance of infecting (endemic) strain for treatment efficacy, dynamics of immune response to assess infection progress and treatment response | |
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bezetting |
J.E. de Steenwinkel (AIOS), G. de Knegt, M. T. ten Kate (deels) |
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projectleider(s) |
dr. I.A.J.M. Bakker |
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interne samenwerking |
prof. dr. A. van Belkum, dr. J.L. Nouwen, prof.dr. H.A. Verbrugh |
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extramurale financiering |
none |
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externe samenwerking |
dr. D. van Soolingen, Natl. Inst. Publ. Hlth. Environm., Bilthoven, The Netherlands; dr. R.M. Schiffelers, Utrecht Inst. Pharm. Sciences, Utrecht, The Netherlands; dr. R. Hernandez-Pando, Natl. Inst. Med. Sci. Nutr. Salvad. Zubiran, Dept.Pathology, Mexico |
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Protective human antibodies against multi-drug resistant Staphylococcus aureus (AntiStaph) | |
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bezetting |
S. van den Berg (OIO) |
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projectleider(s) |
dr. I.A.J.M. Bakker, prof. dr. A. van Belkum |
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interne samenwerking |
dr. W. van Wamel, drs. N. Verkaik |
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extramurale financiering |
Top Instituut Pharma |
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externe samenwerking |
prof. dr. J.M. van Dijl, University Medical Center Groningen, prof. dr. H. Grundmann, University Medical Center Groningen, dr. K. Leenhouts, Biomade Technology, dr. H. Groen en dr. R. Lageveen, IQ Therapeutics, Groningen |