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Groep Trapman
Androgen regulation and genetics of Prostate Cancer
Groep Trapman
Groep Trapman
Androgen regulation and genetics of Prostate Cancer
Androgen regulated and prostate specific gene expression
The androgen receptor is essential for prostate development and maintenance of prostate function.
Prostate cancer and prostate development
We investigate molecular patterns of mouse prostate development. Expression of selected genes is compared with the expression of the human orthologue in different stages of prostate cancer growth.
Jan Trapman, PhD
Principal Investigator, Professor
The androgen receptor in prostate cancer
Dihydrotestosterone (DHT) is essential in the initial growth of prostate cancer.
Mouse prostate cancer models
Progress towards the understanding of the biology of prostate cancer would benefit from the availability of genetically well-defined animal models, which display the full range of clinical stages of the disease.
Molecular Genetics of Prostate Cancer
In our program we study the mechanism of genomic instability, the Pten signal transduction pathway and the roles of genes on chromosome arms 8p and 6q in prostate cancer.
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