Sabine Mous, MSc.
Tel: +31 10 703 8489
Dept. of Child & Adolescent Psychiatry/Psychology
Generation R, room NA-2809
P.O. Box 2040
3000 CA Rotterdam
‘Brain morphology and FGN in Attention-deficit Hyperactivity Disorder’
Attention-deficit Hyperactivity Disorder (ADHD) is a neurobehavioral developmental disorder that affects about 3-7% of children worldwide. However, to date little is known about the underlying neurobiology of this very common childhood disorder. In this project the neurobiological pathways in ADHD will be examined, using a combination of imaging and genetics.
Previous structural and functional imaging studies in ADHD have indicated the involvement of a large number of different brain regions. Additionally, twin and family studies have indicated that ADHD is highly heritable and that, presumably, thousands of alleles contribute to the risk of ADHD.
In the current project we will attempt to identify functional gene networks (FGN) that are associated with ADHD and test the relation of those gene networks with abnormalities in brain morphology related to ADHD.
This PhD project is embedded in the Generation R Study, a population-based prospective cohort study from foetal life until young adulthood. The Generation R Study is designed to identify early environmental and genetic causes of normal and abnormal growth, development, behaviour, and health (http://www.generationr.nl).
- Imaging Genetics
- Pediatric psychopathology
- Brain development
- Cognitive and behavioral development