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Baarends, Willy

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Willy Baarends received her PhD from Erasmus University Rotterdam in 1995, where she cloned the anti-müllerian hormone type II receptor, and studied the gonadal expression of this receptor. Subsequently, she worked as a post-doc, in the Erasmus MC Department of Reproduction and Development.

At present, she holds a tenured position as a staff member at this department. Her current work involves research on the regulation of chromatin structure and gene expression during gametogenesis. This includes studies on the function of the postreplication DNA repair enzymes HR6A and HR6B in these processes. In addition, she aims to elucidate the role of several double strand break DNA repair proteins in meiosis.

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Selected publications

Schoenmakers S,  Wassenaar E, Hoogerbrugge JW, Laven JS, Grootegoed JA, and Baarends WM. (2009)
Female meiotic sex chromosome inactivation in chicken.
Plos Genetics, 5(5):e1000466

Inagaki A, van Cappellen WA, van der Laan R, Houtsmuller AB, Hoeijmakers JH, Grootegoed JA, and Baarends WM. (2009)
Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.
DNA Repair (Amst) 8(2): 190-201

Schoenmakers S, Wassenaar E, van Cappellen WA, Derijck AA, de Boer P, Laven JS, Grootegoed jA, and Baarends WM. (2008)
Increased frequency of asynapsis and associated meiotic silencing of heterologous chromatin in the presence of irradiation-induced extra DNA double strand breaks.
Dev Biol 317: 270-281

Baarends WM, Wassenaar E, Hoogerbrugge J, Schoenmakers S, Sun Z-W, and Grootegoed JA. (2007)
Increased phosphorylation and dimethylation of XY body histones in the Hr6b knockout mouse is associated with derepression of the X chromosome
J Cell Sci 120, 1841-1851

Baarends WM, Wassenaar E, van der Laan R, Hoogerbrugge JW, Sleddens-Linkels E, Hoeijmakers JH, de Boer P and Grootegoed JA. (2005)
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis
Mol Cell Biol 25, 1041-1053

van der Laan R, Uringa EJ, Wassenaar E, Hoogerbrugge JW, Sleddens-Linkels E, Odijk H, Roest HP, de Boer, P, Hoeijmakers JH, Grootegoed JA and Baarends WM. (2004)
Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.
J Cell Sci 117, 5023-5033

Baarends WM, Wassenaar E WHJ, van Cappellen G, Roest HP, Vreeburg JT, Ooms MP, Hoeijmakers JH, and Grootegoed JA (2003)
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase
Mol Cell Biol 23:1151-1162