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Cupedo, Tom

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Tom Cupedo received his PhD from the Free University of Amsterdam, and did his postdoctoral training at the lab of Hergen Spits at the AMC in Amsterdam. During this time he initiated studies into the development of human fetal lymphoid organs and described the appearance of regulatory T cell subsets during human ontogeny.

In the department of Hematology of the Erasmus MC he runs an independent research group that is unraveling the cells and signals involved in the formation and organization of lymphoid organs in humans and mice. Current research interests include the interactions between the hematopoietic and non-hematopoietic cells in human lymphoid organs, the generation of 3D culture systems to recapitulate lymphoid organogenesis, and the modulation of the lymphoid microenvironment by malignant lymphocytes.


N.K. Crellin, S. Trifari, C.D. Kaplan, T. Cupedo and H. Spits (2010)
Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
J Exp Med 15;207:281-90

E. Vivier, H. Spits and T. Cupedo (2009)
Interleukin-22-producing innate lymphocytes: new players in mucosal immunity and tissue repair
Nature Rev Immunol 9:229-34 (review)

T. Cupedo, N.K. Crellin, N. Papazian, E.J. Rombouts, K. Weijer, J.L. Grogan, W.L. Fibbe, J.J. Cornelissen and H. Spits (2009)
Human lymphoid tissue inducer cells are IL17-producing precursors to CD127+RORC+ NK cells
Nature Immunol 10:66-74

K.Hoorweg and T. Cupedo (2008)
Development of human lymph nodes and Peyer’s patches
Semm Immunol 3:164-70

Cupedo T, Jansen W, Kraal G, and Mebius RE (2004)
Induction of secondary and tertiary lymphoid structures in the skin
Immunity 21: 655-67