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Demmers, Jeroen

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Jeroen DemmersJeroen Demmers (1975) studied Chemistry and graduated from Utrecht University in 1998. He earned his PhD degree from the same university in 2002 - his work in the groups of Albert Heck and Antoinette Killian focused on the development of tools to study the interactions of transmembrane peptides and proteins with phospholipid bilayers using hydrogen-deuterium exchange in combination with electrospray ionization mass spectrometry. In 2003, he was awarded an NWO Talent Fellowship and moved to the lab of Brian Chait at The Rockefeller University (New York) to work on a project involving the proteomic identification of plasmid DNA binding proteins in yeast.

 

He came to Erasmus Medical Center in 2005 with an EUR Fellowship to initiate a mass spectrometry and proteomics facility and to set up his own line of research. Currently, he is an assistant professor of proteomics and in his position of head of the proteomics facility he is responsible for initiating and maintaining collaborative projects within Erasmus Medical Center and with other research groups in The Netherlands and abroad. In addition, he is involved in the Netherlands Proteomics Center as a facility manager and he will be a theme leader within the national Proteins@Work consortium (starting 2014).

Current projects focus on the role of specific subunits of the cellular proteasome machinery for which quantitative proteomics technologies (SILAC) in combination with RNAi knockdown strategies are used. Dysregulation of the ubiquitin proteasome system has been implicated in e.g. neurodegenerative diseases, autoimmune diseases and cognitive disorders. Proteasome inhibitors have effective anti-tumor activity, inducing apoptosis by disrupting the regulated degradation of pro-growth cell cycle proteins and are therefore used as chemotherapeutic agents. Demmers’ group investigates how the cellular proteome changes upon proteasome malfunctioning and to what extent ubiquitin conjugation to target proteins is affected. Other projects involve the characterization of multi-protein complexes and protein-protein interactions and focus on technology improvements, such as the development of tools for the specific enrichment of subproteomes such as the ubiquitinome and the phosphoproteome.

 

Proteomics Center


Selection of recent publications

V. Stalin Raj, Huihui Mou, Saskia L. Smits, Dick H. W. Dekkers, Marcel A. Müller, Ronald Dijkman, Doreen Muth, Jeroen A. A. Demmers, Ali Zaki, Ron A. M. Fouchier, Volker Thiel, Christian Drosten, Peter J. M. Rottier, Albert D. M. E. Osterhaus, Berend Jan Bosch & Bart L. Haagmans (2013)
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Nature 495:251–254

Schwertman, P., Lagarou, A., Dekkers, D. H. W., Raams, A., van der Hoek, A. C., Laffeber, C., Hoeijmakers, J. H. J., Demmers, J. A. A., Fousteri, M., Vermeulen, W. & Marteijn, J. A. (2012)
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair
Nature Genetics 44:598-602

Adone Mohd-Sarip, Anna Lagarou, Ulku Aslan, Jan van der Knaap, Cecile Doyen, Karel Bezstarosti, Yasmin Yassin, Hugh W Brock, Jeroen AA Demmers & C. Peter Verrijzer (2012)
Transcription-independent function of the Polycomb group protein PSC in cell cycle control
Science 336:744-747

Yuri M Moshkin, Tsung Wai Kan, Henry Goodfellow, Karel Bezstarosti, Robert K Maeda, Maxim Pilyugin, Francois Karch, Sarah Bray, Jeroen AA Demmers & Peter Verrijzer (2009)
Histone Chaperone ASF1 Cooperates with a LID/KDM5 Histone H3K4me2/3 Demethylase Complex to Mediate Gene-Selective Silencing
Mol Cell 35:782-793

van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA (2010)
An Oct4-centered protein interaction network in embryonic stem cells
Cell Stem Cell 6:369-381

Karel Bezstarosti, Alireza Ghamari, Frank G. Grosveld, Jeroen A. A. Demmers (2010)
Differential proteomics based on 18O labeling to determine the Cyclin Dependent Kinase 9 interactome
J Proteome Res 9:4464-4475


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