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Farrell, Eric

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Eric Farrell

Farrel_200x370Eric Farrell graduated second in his class with a degree in Physiology from Trinity College Dublin, Ireland, in 2002. He subsequently carried out his PhD in tissue engineering between the departments of Physiology and the Trinity Centre for Bioengineering focusing on the generation of bone and cartilage constructs from adult mesenchymal stem cells and the signalling mechanisms involved, graduating in 2006. He then completed a 2 year postdoctoral fellowship in the Trinity Centre for Bioengineering and Anatomy Department of the Royal College of Surgeons in Ireland. This period also included a 6 month period in the Orthopaedics Department of Erasmus Medical Centre in Rotterdam. Research areas included focusing on in vivo repair of critical sized skeletal defects, in vitro angiogenesis and cell tracking using magnetic resonance imaging (MRI).
In 2007 Eric returned to Erasmus where he successfully applied for a Marie Curie fellowship, working in the Departments of Orthopaedics and Otorhinolaryngology. This personally awarded fellowship for career advancement involved the development of an in vitro model of endochondral ossification and neovascularisation. Other ongoing work focused on in vivo stem cell tracking with MRI and the induction of angiogenesis from mesenchymal stem cells to improve the viability of tissue engineered constructs in vivo.
In 2009 Eric returned to Ireland to work in the Regenerative Medicine Institute working on an EU funded project entitled “Gene Activated Matrices for Bone and Cartilage Repair in Osteoarthritis”. There he examined the role of inflammation modulation in prevention of osteoarthritis and also endochondral ossification as a means to effect osteochondral repair in joint defects.
As of October 2012 Eric has returned to Erasmus MC and works as an assistant professor in the Department of Oral and Maxillofacial Surgery. There he has established a research group focused on the treatment of large bone defects by tissue engineering and regenerative medicine approaches. Eric’s research interests are in mimicking the biological process of endochondral ossification to tissue engineer new bone for the treatment of bone defects and in understanding the mechanisms of action of this process by studying the donor/host interactions (immunologically) and the role of specific factors in the process (via lentiviral knockdown). By understanding how implanted stem cells interact with host systems Eric hopes to improve tissue engineering based strategies for tissue repair.

Selected publications

Farrell E, Both S, Ödorfer KI, Koevoet W, Kops N, O’Brien FJ, Baatenburg de Jong RJ, Verhaar JA, Cuijpers V, Jansen J, Erben RG, van Osch GJVM (2011) In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells. BMC Musculoskeletal Disorders 12(1):31.

Verseijden F, Posthumous van Sluijs S, Pavljasevic P, van Neck H, Hovius S, Hofer S, van Osch GJVM, Farrell E (2010) Adult human bone marrow- and adipose tissue-derived stromal cells support the formation of prevascular-like structures from endothelial cells in vitro. Tissue Engineering Part A 16 (1) 101-14.
Farrell E, van der Jagt O, Koevoet W, Kops N, Hellingman CA, O’ Brien FJ, Weinans H, van Osch GJVM (2009) Chondrogenic Priming of human bone marrow stromal cells; A better route to bone repair? Tissue Engineering Part C 15, 2, 285-295.

Farrell E, Wielopolski PA, Jahr, H, Verhaar J, Weinans H, Krestin GP, O’Brien FJ, van Osch GJVM, Bernsen MR (2008) Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo. Biochemical and Biophysical Research Communications 369, 1076-1081.

Farrell E, O'Brien F.J., Doyle P., Fischer J, Yannas I, Harley BA, O'Connell B, Prendergast PJ & Campbell VA. (2006) A Collagen-glycosaminoglycan Scaffold Supports Adult Rat Mesenchymal Stem Cell Differentiation Along Osteogenic and Chondrogenic Routes. Tissue Engineering 12, 459-468.