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Fodde, Riccardo

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Riccardo Fodde studied biology and molecular genetics at the University of Pavia, Italy. His PhD work on hemoglobins and haptoglobins has been carried out at the Dept. of Human Genetics of the University of Leiden, and has led to the characterization of the spectrum of mutations leading to haemoglobinopatheis in The Netherlands. In 1990 he started his post-doctoral work on the molecular genetic basis of colorectal cancer within the same department. As a fellow of the Royal Dutch Academy of Science (KNAW) he visited the laboratory of prof. Raju Kucherlapati at the A. Einstein College of Medicine in New York, where he developed the first targeted mouse model for intestinal tumorigenesis.

In 2001, he became full professor of Cancer Genetics at the Center for Human & Clinical Genetics of the Leiden University Medical Center (LUMC). His group has contributed to the elucidation of the molecular basis of hereditary colorectal cancer in man, developed a large number of pre-clinical mouse models for colorectal carcinogenesis, and characterized novel functional aspects of the APC tumor suppressor gene. Most recently, the focus of his research has been centered around the role of Wnt/β-catenin signaling in embryonic and stem cell differentiation and in the onset of cancer stemness. Also, based on the recent identification of the hitherto elusive quiescent stem cell of the intestinal epithelium, his research is now focusing on the role of these cells in inflammation and cancer. In 2002 he became full member of EMBO. Since 2003 he is professor of Experimental Pathology at the Josephine Nefkens Institute of the Erasmus Medical Centre in Rotterdam.

Gaspar C, Franken P, Molenaar L, Breukel C, van der Valk M, Smits R, Fodde R (2009).
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
PLoS Genet. Jul;5(7):e1000547.

Fodde R (2009)
The stem of cancer.
Cancer Cell. Feb 3;15(2):87-9.

Fodde R, Brabletz T. (2007)
Wnt/β-catenin signaling in cancer stemness and malignant behavior.
Curr Opin Cell Biol. 2007 Apr;19(2):150-8.

Kielman M, Rindapää M, Gaspar C, van Poppel N, Breukel C, van Leeuwen S, Taketo M, Roberts S, Smits R, and Fodde R (2002)
The Apc tumor suppressor gene defines and modulates embryonic stem cell differentiation by controlling the dosage of beta-catenin signaling
Nature Genet 32:594-605

Fodde R, Smits R, Clevers H. (2001)
APC, signal transduction and genetic instability in colorectal cancer.
Nat Rev Cancer. Oct;1(1):55-67.

Fodde R, Kuipers J, Rosemberg C, Smits R, Kielman M, Gaspar C, van Es J, Breukel C, Giles R, Clevers H (2001)
Mutations in the APC tumor suppressor gene cause chromosomal instability
Nature Cell Biol 3:433-438

Smits R, Kielman MF, Breukel C, Zurcher C, Neufeld K, Jagmohan-Changur S, Hofland N, van Dijk J, White R, Edelmann W, Kucherlapati R, Khan PM, Fodde R (1999)
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
Genes Dev 13:1309-1321