target menu

Fornerod, Maarten

Back to List


Foto Fornerod, Maarten 

Maarten Fornerod 
Department of Cell Biology
Email contact:

Maarten Fornerod is specialized in understanding cellular processes using a combination of molecular and bioinformatics approaches. He started as a PhD student in the lab of Gerald Grosveld (Rotterdam and Memphis, TN), where he struggled to understand the role of the t(6;9) translocation gene product in acute myeloid leukemia. Without solving this question, he cloned the human CRM1 protein based on a single Edman degradation peptide, derived from a massive co-immunoprecititation experiment and identified a large family of potential nucleocytoplasmic transport factors (1997). As fun project on the side, he identified, together with Arnoud van der Spoel and Alessandra d'Azzo, a human lysosomal neurominidase cDNA in silico, using a word based approach (1996). Translocating across the Atlantic, he joined the lab of Iain Mattaj at the European Molecular Biology institute, where, together with Mutsuhito Ohno, he identified CRM1 as a nuclear export for nuclear export signal (NES) containing proteins and renamed the protein exportin1 or XPO1 (1997), which continues to be a citation classic.

He set up his own lab at the Netherlands Cancer Institute, where his most important work was the the genome-wide identification of lamin / chromatin interaction in Drosophila (2006) together with Bas van Steensel, and the idenification of nucleoplasmic roles of nuclear pore components (2010).

Relocating to Rotterdam he associated as an associate professor with the departments of Biochemistry, Pediatric Oncology and Cell Biology, where he keeps providing new cell biological insights, relevant for both fundamental biological understanding and clinical applicability.

Full citation profile

Key publications

de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang
J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den
Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA. Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet. 2017 Mar;49(3):451-456. doi: 10.1038/ng.3772. Epub 2017 Jan 23. PubMed PMID: 28112737.

[Fornerod M. Nieuwe stratificatie van acute megakaryoblastenleukemie bij kinderen door ‘next-generation sequencing’-technologie. Nederlands Tijdschrift voor Hematologie 14:307-9.]
(ik weet niet of deze link meerdere keren werkt)

Kalverda B, Pickersgill H, Shloma VV, Fornerod M. Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Cell. 2010 Feb 5;140(3):360-71. doi: 10.1016/j.cell.2010.01.011.
PubMed PMID: 20144760.

Pickersgill H, Kalverda B, de Wit E, Talhout W, Fornerod M, van Steensel B.
Characterization of the Drosophila melanogaster genome at the nuclear lamina. Nat Genet. 2006 Sep;38(9):1005-14. Epub 2006 Jul 30. PubMed PMID: 16878134.

Fornerod M, Ohno M, Yoshida M, Mattaj IW. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 1997 Sep 19;90(6):1051-60. PubMed
PMID: 9323133.