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Hendriks, Rudi

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Rudi Hendriks did his PhD studies on X chromosome inactivation patterns in human X-linked immunodeficiency diseases in the Department of Immunohaematology (Prof. J.J. van Rood). After a post-doctoral training in the Genetics Laboratory of the University of Oxford, where he studied genetic aspects of X chromosome inactivation, he received a Royal Academy of Arts and Sciences fellowship and started his own line of research within the lab of Frank Grosveld at the Department of Cell Biology and Genetics of the Erasmus MC Rotterdam. In 1999 he moved his group to the Department of Immunology at the Erasmus MC, and, more recently, to the Department of Pulmonary Medicine.

His research focuses on the molecular biology of the developmental program of B and T lymphocytes. The largest effort has gone into the generation of transgenic and knock-out mice to investigate the role of Bruton's tyrosine kinase, the gene defective in the human immunodeficiency disease X-linked agammaglobulinemia. These studies identified novel functions for Btk in pre-B cells, as a regulator of immunoglobulin light chain rearrangements and as a tumor suppressor that limits pre-B cell expansion. The aims comprise the characterization of signal transduction pathways and lymphoid-specific transcription factors that implement cell fate decisions at specific checkpoints, controlled by antigen receptors and their immature forms.

The research laboratory of the Department of Pulmonary Medicine focuses on clinical and translational research concerning the pathology of various respiratory disorders. In this context, we study the molecular biology of the differentiation program of T helper subsets and to identify their role in the pathogenesis of various inflammatory diseases, including asthma, pneumonia and sarcoidosis. In addition, we study the role of dendritic cells in directing and maintaining immune responses in the lung, e.g. in influenza virus infection or in asthma. Hereby, we focus on signal transduction pathways downstream of Toll-like receptors in particular. Finally, we aim to develop dendritic-cell based immunotherapy in mesothelioma, a tumor caused by asbestos fibre inhalation.

 

Key publications

Van Loo PF, Dingjan GM, Maas A, and Hendriks RW (2007)
Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling
Immunity 27:468-680

Ter Brugge PJ, Ta VBT, de Bruijn MJW, Keijzers G, Maas A, van Gent DC, and Hendriks RW (2009)
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen
Blood 114:119-127

Geurts van Kessel CH, Willart MA, Bergen I, van Rijt LS, Muskens F, Elewaut D, Osterhaus AD, Hendriks RW, Rimmelzwaan GF, and Lambrecht BN (2009)
Dendritic cells are crucial for maintenance of tertiary lymphoid tissue in the lung of influenza virus infected mice
J Exp Med 206:2339-2349

Ta VBT, De Bruijn MJW, Ter Brugge PJ, Van Hamburg JP, Diepstraten H, Van Loo, PF, Kersseboom R, and Hendriks RW (2010)
Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf–Mdm2–p53 tumor suppressor  pathway
Blood 115:1385-1393

Hegmans JPJJ, Veltman JD, Lambers MEH, De Vries IJ, Figdor CG, Hendriks RW, Hoogsteden HC, Lambrecht BN, and Aerts JG (2010)
Consolidative dendritic cell-based immunotherapy elicits cytotoxicity against malignant mesothelioma
Am J Resp Crit Care Med 181:1383-1390

Ten Berge B, Paats MS, Van den Blink B, Hoogsteden HC, Lambrecht BN, Hendriks RW, and KleinJan A (2011)
Increased IL-17a expression in granulomas and in circulating memory T cells in sarcoidosis
Rheumatology (in press)

Ribeiro de Almeida C, Stadhouders R, de Bruijn MJW, Bergen IM, Thongjuea S, Lenhard B, Van IJcken W, Grosveld FG, Galjart NJ, Soler E, and Hendriks RW (2011)
CTCF insulator function limits proximal V k gene segment recombination and restricts intronic and 3’ enhancer interactions within the immunoglobulin  k light chain locus
Immunity (in press)