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Keizer, Peter de

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Peter de Keizer

PeterdeKeizer200xPeter de Keizer received his PhD from Utrecht University Medical Center in 2009 for his work on FOXO transcription factors in tumor suppression. He received his postdoctoral training at the Buck Institute for Research on Aging in Novato, CA, USA on the molecular hallmarks of cellular senescence.
His research focusses on the role of senescence in aging and cancer. Senescence has been causally linked to age-related diseases, but not therapeutic methods exist to remove senescent cells from an organism. His goal is to develop these, something which he dubbed TASC (Targeted Apoptosis of Senescent Cells). His second focus lies on targeting chemoresistance in metastatic cancer. He found certain senescence-associated proteins to be associated with therapy resistance and developed methods to overcome this.
In 2010 he was elected as a fellow of the Dutch Cancer Society (KWF) and in 2014, he was awarded the prestigious “Talent Extraordinary Award” from the Erasmus University Medical Center.

Keywords: Senescence, Aging, Cancer, Melanoma, Mammary Carcinoma, FOXO


Kruiswijk F., Hasenfuss S., Sivapatham R., Naipal K., van den Broek N.J.F., Kruit W., van der Spek P., van Gent D., Brenkman A.B., Campisi J., Burgering B.M.T., Hoeijmakers J.H.J. and de Keizer P.L.J. “Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling”.
Oncogene, Acceptance pending revision

de Keizer P., Burgering B, Dansen TB. “FOXO as a sensor, mediator and regulator of redox signaling”
Antioxid. Redox Signal. 2011 Mar 15;14(6):1093-106.

de Keizer P.L.*, Laberge R.M.*, Campisi J. “p53: Pro-aging or pro-longevity?”
Aging (Albany NY). (2010) Jul;2(7):377-9. * These authors contributed equally.

de Keizer P.L.J., Riedl-Polderman P.E., Szypowska A.A., Packer L.M., van den Broek N.J.F., Dansen T.B., Marais R., Brenkman A.B., Burgering,B.M.T. "Activation of FOXO transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence"
Cancer Res. (2010) Nov 1;70(21):8526-36.

Brenkman A.B., van den Broek N.J.F., de Keizer P.L.J., van Gent D., Burgering B.M.T. “The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response.”
FASEB J. (2010) Nov;24(11):4271-80.

de Keizer P.L.*, Brenkman A.B.*, van den Broek N.J., van der Groep P., van Diest P.J., van der Horst A., Smits A.M., Burgering B.M. "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors."
Cancer Res. 68(18), 7597 (2008). * These authors contributed equally.

Patents and Intellectual Properties
de Keizer PLJ, Laberge RM, Campisi J
Targeting senescent and cancer cells for selective killing by interference with foxo4 (No: 13/830,790). 2013
de Keizer PLJ, Laberge RM, Campisi J
Targeting senescent cells and cancer cells by interference with JNK and/or foxo4 (No: 13/830,846). 2013