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Lans, Hannes

Hannes Lans


Lans_200
Mechanism and Regulation of Nucleotide Excision Repair


Hannes Lans received his Ph.D. from the Erasmus University, Rotterdam, The Netherlands, in 2005. Currently, he is an assistant professor at the Department of Genetics, Erasmus MC. His research focuses on the mechanism and regulation of Nucleotide Excision Repair (NER). This major DNA repair pathway removes many types of helix-distorting DNA lesions from the genome and is therefore essential to protect against cancer and aging.

Using mammalian and C. elegans cell biological and genetic tools, we aim to understand the mechanisms that control NER activity. We are particularly interested in the role that chromatin organization plays in regulating access and activity of NER proteins.  Furthermore, we aim to understand how the DNA damage response is organized in vivo, in the different cell types of multicellular organisms.

For more information, email to w.lans(at)erasmusmc.nl or visit www.vermeulenlab.com/hannes-lans

Selected publications

Sabatella M, Theil AF, Ribeiro-Silva C, Slyskova J, Thijssen K, Voskamp C, Lans H, Vermeulen W (2018) Repair protein persistence at DNA lesions characterizes XPF defect with Cockayne syndrome features.
Nucleic Acids Res doi: 10.1093/nar/gky774

Slyskova J, Sabatella M, Ribeiro-Silva C, Stok C, Theil AF, Vermeulen W, Lans H (2018) Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage.
Nucleic Acids Res doi: 10.1093/nar/gky764

Mandemaker IK, Geijer ME, Kik I, Bezstarosti K, Rijkers E, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA (2018) DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.
EMBO Rep  doi: 10.15252/embr.201745566.

Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W (2018) The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage.
Nucleic Acids Res. 46:7747-7756

Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA (2017) DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.
Sci Rep. 7:15353

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG (2015) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.
J Neuroscience 35:14286-306

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA (2015) SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair
Nat Commun 6:7499.

Lans H, Vermeulen W (2015) Tissue specific response to DNA damage: C. elegans as role model DNA Repair 32:141-148

Aydin OZ, Vermeulen W, Lans H (2014) ISWI chromatin remodeling complexes in the DNA damage response
Cell Cycle 13:3016-3025
 
Aydin OZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription
Nucleic Acids Res. 42:8473-8485

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH (2014) Understanding nucleotide excision repair and its roles in cancer and ageing
Nat Rev Mol Cell Biol 15:465-81

Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. (2013) DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals
Cell Death Differ 20:1709-18

Lans H, Hoeijmakers JH (2013) Genome stability, progressive kidney failure and aging
Nat Genet 44:836-8

Lans H, Marteijn JA, Vermeulen W (2012) ATP-dependent chromatin remodeling in the DNA-damage response
Epigenetics Chromatin 5:4

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W (2010) Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development
PLoS Genet 6:e1000941

Lans H, Hoeijmakers JH (2006) Cell biology: ageing nucleus gets out of shape
Nature 440:32-4