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Lans, Hannes

Hannes Lans

Mechanism and Regulation of Nucleotide Excision Repair

Hannes Lans received his Ph.D. from the Erasmus University, Rotterdam, The Netherlands, in 2005. Currently, he is an assistant professor at the Department of Genetics, Erasmus MC. His research focuses on the mechanism and regulation of Nucleotide Excision Repair (NER). This major DNA repair pathway removes many types of helix-distorting DNA lesions from the genome and is therefore essential to protect against cancer and aging.

Using mammalian and C. elegans cell biological and genetic tools, we aim to understand the mechanisms that control NER activity. We are particularly interested in the role that chromatin organization plays in regulating access and activity of NER proteins. Furthermore, we aim to understand how the DNA damage response is organized in vivo, in the different cell types of multicellular organisms.

For more information, email to w.lans(at) or visit

Selected publications

Aydin OZ, Vermeulen W, Lans H (2014) ISWI chromatin remodeling complexes in the DNA damage response
Cell Cycle 13:3016-3025

Aydin OZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription
Nucleic Acids Res. 42:8473-8485

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH (2014) Understanding nucleotide excision repair and its roles in cancer and ageing
Nat Rev Mol Cell Biol 15:465-81

Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. (2013) DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals
Cell Death Differ 20:1709-18

Lans H, Hoeijmakers JH (2013) Genome stability, progressive kidney failure and aging
Nat Genet 44:836-8

Lans H, Marteijn JA, Vermeulen W (2012) ATP-dependent chromatin remodeling in the DNA-damage response
Epigenetics Chromatin 5:4

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W (2010) Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development
PLoS Genet 6:e1000941

Lans H, Hoeijmakers JH (2006) Cell biology: ageing nucleus gets out of shape
Nature 440:32-4