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Osch, Gerjo van

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Gerjo van Osch (1967) studied medical biology at the University of Utrecht (MSc 1990) and received her PhD in 1994 at the University of Nijmegen on animal models for osteoarthritis. Since then she became involved in cartilage tissue engineering and especially the use of growth factors. She is currently appointed as full professor at the Erasmus MC, University Medical Center in Rotterdam the Netherlands where she is leading a research group of approx. 12 people that is part of the departments of Orthopaedics and Otorhinolaryngology, focusing on cellular aspects of connective tissue degeneration and regeneration.

Gerjo van Osch is (co-)author on over 100 international peer-reviewed publications. She is active in various committees of the International Cartilage Repair Society (ICRS), is presently vice chair of the European Science Foundation network on Regenerative Medicine, REMEDIC, associate editor of Cartilage and editorial board member of Tissue Engineering and Journal of Tissue Engineering and Regenerative medicine. In addition she served as council member of the European chapter of the TERMIS and chaired the TERMIS-EU meeting in Rotterdam in 2006.

MScMM faculty - Gerjo van Osch with lab membersMain research interests
The Connective Tissue Cells and Repair group of the department of Orthopaedics and the department of Otorhinolaryngology performs translational research from a cell biological view point. The central research question of the research is:  “what drives cells in degenerating and regenerating connective tissues?”  The focus lies on anabolic processes in tissue repair. Tissue repair processes play a role in pathophysiology as well as in therapy.

In degenerative diseases of connective tissues of the musculoskeletal system, like osteoarthritis and tendinosis, repair processes occur as response to wounds, overloading or inflammation. If the repair is not appropriate, the extra-cellular matrix formed is of inferior quality contributing to a progressive degeneration of the tissues. We study disease mechanisms using several cell and tissue culture models as well as animal experiments.

To repair lesions in connective tissues we aim to use tissue engineering and cell therapeutic procedures. Different factors are used in order to direct cells to differentiate towards a certain phenotype or to generate the desired matrix. For our studies we use a variety of different donor cell sources (e.g. different types of  chondrocytes as well as adult stem cells from bone marrow and adipose tissue) and we aim to control cellular differentiation and the quality of the extracellular matrix produced.
We perform translational research from a cell biological view point in a group consisting of people with different backgrounds appointed to different departments.

Van Osch group webpages


Key publications

Bastiaansen-Jenniskens YM, Clockaerts S, Feijt C, Zuurmond AM, Stojanovic-Susulic V, Bridts C, de Clerck L, DeGroot J, Verhaar JA, Kloppenburg M, van Osch GJVM (2012)
Infrapatellar fat pad of patients with end-stage osteoarthritis inhibits catabolic mediators in cartilage
Ann Rheum Dis 71(2):288-94

Beekhuizen M, Bastiaansen-Jenniskens YM, Koevoet W, Saris DB, Dhert WJ, Creemers LB, van Osch GJ (2011)
Osteoarthritic synovial tissue inhibits proteoglycan production in human osteoarthritic cartilage; Establishment and characterisation of a long-term coculture
Arthritis Rheum 63(7):1918-27

Hellingman CA, Davidson EN, Koevoet W, Vitters EL, van den Berg WB, van Osch GJ, van der Kraan PM (2011)
Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification
Tissue Eng Part A 17(7-8):1157-67

van Buul GM, Kotek G, Wielopolski PA, Farrell E, Bos PK, Weinans H, Grohnert AU, Jahr H, Verhaar JA, Krestin GP, van Osch GJ, Bernsen MR (2011)
Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides
PLoS One 6(2):e17001

Hellingman CA, Koevoet W, Kops N, Farrell E, Jahr H, Liu W, Baatenburg de Jong RJ, Frenz D, van Osch G (2010)
Fibroblast Growth Factor Receptors in in-vivo chondrogenesis: Relating tissue engineering using adult mesenchymal stem cells to embryonic development
Tissue Eng Part A 16:545-556