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Spek, Peter van der

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Peter J. van der Spek has been appointed as professor and head of the department of bioinformatics at the Erasmus MC. He obtained his doctoral degree in 1995 in the field of molecular carcinogenesis by cloning cancer predisposition genes.

Van der Spek has 6 years of pharmaceutical experience from Akzo-Nobel and Johnson & Johnson and holds several international academic appointments in Japan, Australia and USA. The bioinformatics group at the Erasmus MC focuses on the support of datamining and analysis. This expertise is used for fundamental research, molecular diagnostics, molecular imaging, (forensic) molecular biology and support of clinical trials. Erasmus MC is one of the largest medical centers of the Netherlands. Van der Spek runs a neuroscience research program which provides the biological and technological basis for the bioinformatics group. It concentrates on the way the genome as a whole contributes to the evolution, development, structure and function of the brain.


Ton van Agthoven, Thecla L.A. van Agthoven, Anita Dekker, Peter J. van der Spek, Lilian Vreede and Lambert C.J. Dorssers (1998)
Identification of BCAR3 by random search for genes involved in anti-estrogen resistance of human breast cancer cells
EMBO Journal 17(10):2799-2808

Kaoru Sugasawa, Jessica M.Y. Ng, Chikahide Masuitani, Shigenori Iwai, Peter J. van der Spek, Andre P.M. Eker, and Jan H.J. Hoeijmakers (1998)
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair
Molecular Cell 2:223-232

Frans W. Verheijen, Elly Verbeek, Nina Aula, Cecile E. M.T. Beerens, Adrie C. Havelaar, Marijke Joosse, Leena Peltonen, Pertti Aula, Hans Galjaard, Peter J. van der Spek and Grazia M. S. Mancini (1999)
A novel anion transporter gene is mutated in sialic acid storage diseases
Nature Genetics 23:462-465

Sheau Yu Hsu, Masataka Kudo, Thomas Chen, Koji Nakabayashi, Alka Bhalla, Peter J. van der Spek, Marcel van Duin, and Aaron Hsueh (2000)
The three subfamilies of leucine-rich repeat containing G protein-coupled receptors (LGR): Identification of LGR6 and LGR7 and the signaling mechanism for LGR7
Molecular Endocrinology 1257-1271

Yamamoto S, Watanabe Y, van der Spek PJ, Watanabe T, Fujimoto H, Hanaoka F, Ohkuma Y (2001)
Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation
Mol Cell Biol 21(1):1-15

Peeters JK and Van der Spek PJ (2005)
Growing applications and advancements in microarray technology and analysis tools
Cell Biochem Biophys 43(1):149-66

Van Vlierberghe P, van Grotel M, Tchinda J, Lee C, Beverloo HB, van der Spek PJ, Stubbs A, Cools J, Nagata K, Fornerod M, Buijs-Gladdines J. Horstmann M, van Wering ER, Soulier J, Pieters R, Meijerink JP (2008)
The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia
Blood, Feb 25