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Uitterlinden, André

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André Uitterlinden

Uitterlinden_200x266André Uitterlinden is Professor of Complex Genetics at the Erasmus Medical Centre in Rotterdam – The Netherlands - where he holds positions in 3 departments: Internal Medicine, Epidemiology and Clinical Chemistry.

His research is focusing on genetic factors for common traits and disease, including anthropometry, endocrine traits & disorders and locomoter disease such as osteoporosis and osteoarthritis. At Erasmus MC he is also head of one of Europe’s largest high-throughput DNA facility, providing services for DNA isolation, genotyping and sequencing.

As a PI (Personal Investigator) and member of the MT, he is coordinating all molecular genetic analyses in 2 major cohort studies at Erasmus MC: the Rotterdam Study (12,000 elderly subjects) and the Generation R birth-cohort (n=7,000 children +12,000 parents).

He is collaborating with many (large) international epidemiological study populations and coordinates the GEFOS consortium involving >150.000 subjects to identify genetic risk factors for osteoporosis. He is a member of the Research Steering Committee of the CHARGE consortium and director of the Netherlands Consortium for Healthy Aging (NCHA).

He has published 680 papers in refereed journals, has a H-index of 85 and is organizing annual international courses on complex genetics at Erasmus MC.

Uitterlinden group page

Most contributing publications (in chronologic order)

1. Uitterlinden AG et al. Two-dimensional DNA fingerprinting of human individuals.
Proc Natl Acad Sci USA 86:2742-2746 (1989)

2. Muyzer G, de Waal E, Uitterlinden AG. Profiling of complex microbial populations by DGGE analysis of PCR amplified 16S rDNA.
Appl Environ Microbiol 59:695-700 (1993)

3. Uitterlinden AG, et al. Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.
New Engl J Med 338:1016-1021 (1998)

4. van Meurs JBJ, Uitterlinden AG. Homocysteine levels and the risk of osteoporotic fracture.
New Engl J Med 2004 May 13;350(20):2033-41 (2004)

5. Rivadeneira F* et al. Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies.
Nat Genet. 2009, 41, 1199 – 1206 (2009)

6. Lango Allen H*, Estrada K*, Lettre G*, Berndt SI*, Weedon MN*, Rivadeneira F*, et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature 467:832-8 (2010)

7. Stolk L* et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Nat Genet. 2012;44(3):260-8 (2012)

8. Zillikens MC, Uitterlinden AG et al. PLS3 Mutations in X-Linked Osteoporosis and Fractures.
New England Journal of Medicine, 2013 Oct 17; 269(16) 1529-36 (2013)

9.Rietveld CA et al. GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment.
Science, 2013 Jun 21;340(6139):1467-71 (2013)

10.Mayerle J et al. Identification of Genetic Loci Associated with Heliobacter pylori Serologic Status. JAMA, 2013 May 8; 309(18):1912-20 (2013)