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Vermeulen, Wim

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Portret_Wim Vermeulen_200xWim Vermeulen received his PhD in Genetics in 1995 from the Erasmus University where he studied the genetic heterogeneity of mammalian nucleotide excision repair (NER) and biochemical properties of some key NER factors.

In 1998 he started his own group, with which he pioneered novel procedures to quantitatively monitor dynamics of DNA repair and transcription in living mammalian cells. In 2003 he received a VIDI grant from the Dutch Science Organization (NWO) to further exploit the tools developed to quantitatively determine in vivo DNA repair. In 2004 he became associate professor at the Department of Genetics at the Erasmus MC. In 2013 he was awarded with an ERC Advanced grant and as of September 2014 he is appointed as Professor in ‘Genome Stability’ at the Erasmus MC.

Currently the Vermeulen lab is pursuing an integrated multi-disciplinary approach to dissect the molecular networks underlying the DNA damage response. Using a variety of research tools, including patient-derived cell cultures, mouse-models, C. elegans, biochemistry, live cell microscopy and genomic and proteomic approaches, we aim to:

• comprehend the molecular mechanisms of DNA repair

• understand the pathogenesis and clinical ramifications of inherited NER defects

• investigate the pivotal of role of genome stability in cancer

Visit our lab website www.vermeulenlab.com for more information.

Selected publications

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH (2014) Understanding nucleotide excision repair and its roles in cancer and ageing Nat Rev Mol Cell Biol 15:465-81

Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA (2013) Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage Mol Cell 51:469-79

Vermeulen W, Fousteri M (2013) Mammalian transcription-coupled excision repair Cold Spring Harb Perspect Biol 5(8):a012625

Menoni H, Hoeijmakers JH, Vermeulen W (2012) Nucleotide
excision repair-initiating proteins bind to oxidative DNA lesions in vivo J Cell Biol. 199:1037-46

Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA (2012) UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair Nat Genet 44:598-602

Bergink S, Toussaint W, Luijsterburg MS, Dinant C, Alekseev S, Hoeijmakers JH, Dantuma NP, Houtsmuller AB, Vermeulen W (2012) Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex J Cell Biol 196:681-8

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W (2010) Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development PLoS Genet 6:e1000941

Giglia-Mari G, Theil AF, Mari PO, Mourgues S, Nonnekens J, Andrieux LO, de Wit J, Miquel C, Wijgers N, Maas A, Fousteri M, Hoeijmakers JH, Vermeulen W (2009) Differentiation driven changes in the dynamic organization of Basal transcription initiation PLoS Biol 7:e1000220

Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W (2009) Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response J Cell Biol 186:835-47

Bergink S, Salomons FA, Hoogstraten D, Groothuis TA, de Waard H, Wu J, Yuan L, Citterio E, Houtsmuller AB, Neefjes J, Hoeijmakers JH, Vermeulen W, Dantuma NP (2006) DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A Genes Dev 20:1343-52

Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (2004) A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A Nat Genet 36:714-9

Hoogstraten D, Nigg AL, Heath H, Mullenders LH, van Driel R, Hoeijmakers JH, Vermeulen W, Houtsmuller AB (2002) Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo Mol Cell 10:1163-74

Vermeulen W, Rademakers S, Jaspers NG, Appeldoorn E, Raams A, Klein B, Kleijer WJ, Hansen LK, Hoeijmakers JH (2001) A temperature-sensitive disorder in basal transcription and DNA repair in humans Nat Genet 27:299-303

Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (2000) Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder Nat Genet 26:307-13

Houtsmuller AB, Rademakers S, Nigg AL, Hoogstraten D, Hoeijmakers JH, Vermeulen W (1999) Action of DNA repair endonuclease ERCC1/XPF in living cells Science 284:958-61