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Verrijzer, Peter

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Peter Verrijzer studied biochemistry at Utrecht University, The Netherlands and obtained his PhD from the same university (1992) where he studied eukaryotic DNA replication in the laboratory of P. van der Vliet. During his postdoctoral period in the group of Robert Tjian at the University of California at Berkeley he started his work on the basic mechanisms of gene regulation in animal cells. He was involved in the cloning of subunits of the general transcription factor TFIID, its reconstitution and discovered that selective TAF subunits within TFIID determine core promoter selectivity. In 1996 he joined the Imperial Cancer Research Fund in London as a group leader to study the role of chromatin and epigenetic processes in the regulation of development and cell proliferation.

In 1999 he became a full professor of Molecular and Cell Biology at the Leiden University Medical Centre. His group was the first to show functional selectivity among chromatin remodeling factors and contributed to understanding several aspects of the molecular mechanisms by which transcriptional regulators function. Peter Verrijzer is head of the Department of Biochemistry at Erasmus MC.

Verrijzer group page 

Mohd-Sarip, A., van der Knaap, J.A., Wyman, C., Kanaar, R., Schedl, P., and Verrijzer, C.P. (2006)
Architecture of a Polycomb Nucleoprotein Complex
Mol. Cell, in press

Mohd-Sarip, A., Cléard, F., Mishra, R.K., Karch, F., and Verrijzer, C.P. (2005)
Synergistic Recognition of an Epigenetic DNA Element by Pleiohomeotic and a Polycomb Core Complex
Genes Dev. 19: 1755-1760

Vries, R.G.J., Bezrookove, V., Zuijderduijn, L.M.P., Kheradmand Kia, S., Houweling, A, Oruetxebarria, I, Raap, A.K., and Verrijzer, C.P. (2005)
Cancer–associated mutations in chromatin-remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint
Genes Dev. 19: 665-670

Van der Knaap, J.A., Kumar, B.R.P., Moshkin, Y.M., Langenberg, K., Krijgsveld, J., Heck, A.J., Karch, F., and Verrijzer, C.P. (2005)
GMP Synthetase Stimulates Histone H2B Deubiquitylation by the Epigenetic Silencer USP7
Mol. Cell 17: 695-707

Moshkin, Y.U., Armstrong J.A., Maeda, R.K., Tamkun, J.W., Verrijzer, C.P., Kennison, J.A. and Karch, F. (2002)
Histone chaperone ASF1 cooperates with the Brahma chromatin-remodeling machinery
Genes Dev. 16: 2621-2626

Mahmoudi, M., Katsani, K.R. and Verrijzer, C.P. (2002)
GAGA can mediate enhancer function in trans by linking two separate DNA molecules
EMBO J. 21: 1775-1781

Katsani, K.R., Arredondo, J.J., Kal A.J. and Verrijzer, C.P. (2001)
A homeotic mutation in the trithorax SET domain impedes histone binding
Genes Dev. 15: 2197-2202

Kal, A.J., Mahmoudi, T., Zak, N.B. and Verrijzer, C.P. (2000)
The Drosophila Brahma complex is an essential coactivator for the trithorax group protein Zeste
Genes Dev. 14: 1058-1071