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Wyman, Claire

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Prof.dr Claire Wyman

 

Claire Wyman received her PhD in Molecular Biology from The University of California at Berkeley in 1990 in the group of Dr. E. Blackburn, where she studied transposons and transposition events involved in the developmental genome rearrangements of Tetrahymena thermophila. Her postdoctoral work in the laboratory of Dr. H. Echols at the University of California at Berkeley focused on determining the structure of complex nucleoprotein assemblies of DNA replication primarily using electron microscopy. In collaboration with Dr. Carols Bustamante at the University of Oregon she appled the newly developed technique of Scanning Force Microscopy (SFM) to study DNA replication and transcription mechanisms.

In 1996 she joined the Department of Cell Biology and Genetics at the Erasmus Medical Centre.  Here she set up the Centre for Scanning Force Microscopy of Biological Nanomachines to study the molecular machinery involved in DNA repair. This work has led to new understanding of several important functional assemblies of DNA repair machinery and their mechanism of action. In 2005 she was appointed Associate Professor in the Department of Radiation Oncology at the Erasmus MC and continues to apply novel microscopy and molecular manipulation techniques to advance our understanding of complex mechanisms of genome metabolism.

In 2006 she received a VICI award from the Chemical Sciences division of NWO to expand this work in new directions. She is a course director for the MSc Molecular Medicine program at Erasmus MC. Since August 2008 she is Professor of Molecular Radiation Biology. 

Claire Wyman is academic director of the BSc program in Nanobiology, a joint initiative of Erasmus MC and TU Delft, newly started in September 2012.

Wyman group page

 

Publications

Moreno-Herrero,F., M. de Jager, N.H. Dekker, R. Kanaar, C. Wyman and C. Dekker (2005)
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon DNA binding
Nature 473:440-443

Modesti, M., D., Ristic, T. van der Heijden, C. Dekker, J. van Mameren, E.J. Peterma, G.J. Wuite, R. Kanaar, and C. Wyman (2007)
Fluorescent Human RAD51 Reveals Multiple Nucleation Sites and Filament Segments Tightly Associated along a Single DNA Molecule
Structure 15:599-609

van der Heijden, T., Modesti, M., Hage, S., Kanaar, R., Wyman, C., Dekker, C. (2008)
Homologous recombination in real time: DNA strand exchange by RecA
Mol Cell 30:530-538

Holthausen, J., M. van Loenhout, H. Sanchez, D. Ristic, S. van Rossum-Fikkert, M. Modesti, C. Dekker, R. Kanaar, and C. Wyman (2011)
Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques
Nucleic Acids Res 39:6558-6567