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Translational Research

Translational research, performed by the department of Bioinformatics, with collaborators within Erasmus MC and abroad.

Translational medicine has the potential to fuel the advancement of molecular-based medicine by enabling physicians and scientists to leverage systems biology technologies to substantially improve patient care, increase drug development efficiency and drug efficacy, and ultimately, enable personalized medicine. The possibilities of biomarkers to monitor many biological, disease, and treatment states has led to the paradigm of translational medicine and is driving the integration of the clinical and research domains.

The integration of clinical data with cutting-edge molecular profiling data from genomics and proteomics will expedite the transition to molecular-based and personalized medicine. However, this new paradigm requires information and data to flow from discovery-labs to labs in to clinical organizations in an organized and structured format, and flow back from the clinical environment back to the discovery labs.

Patient stratification will more and more help in the diagnostic decision making process in the clinic. Moreover, this forms the basis for targeted therapy. Key to implementation of such technology this is the development of databases and infrastructure for targeted therapy. Experts understand and discuss the need for a multi-disciplinary and team approach to translational medicine. However, to effectively bridge the gap from bench to bedside is important to focus on a holistic and integrated approach to IT systems for clinical and research informatics as well.