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Fundamental Research

The department of Bioinformatics supports fundamental research across various departments of the Erasmus MC

The functionality of the genome is laid down in its sequence, and with microarrays it is possible to probe the expression status of every gene in every tissue at any point in time under various conditions. The human genome provides the basis to address  a number of fundamental questions in modern biology, all aimed at elucidating how the genome actually works. This deals with questions such as; how is the genome physically organized, what is the role of epigenetic interactions, and what are the phenotypic consequences of sequence variations between individuals?
Erasmus MC is clearly in an excellent position to contribute to this rapidly developing research domain. Across the various departments, a large number of population- and disease-based research projects is applied to study biological processes including reproduction, development, behavior, ageing, cell proliferation and differentiation, DNA damage repair and carcinogenesis. These research lines evolve around patients and a number of animal models for human conditions, such as ageing, anemia’s, neurological disorders, leukemia's and cancer research.