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Experimental therapy of Cystic Fibrosis

Bob J Scholte PhD, is group leader and assistant professor (Gene therapy, experimental therapy of lung disease) at Erasmus MC Rotterdam since 1986, presently associated with the Pediatric Pulmonology department, and the Cell biology department (Biomedical Sciences). His team published more than fifty papers in the field of Cystic Fibrosis (CF), and developed a unique mouse model of the most common CF mutation, CFTR F508del (Cftrtm1EUR), which is now widely used in experimental therapy of CF.


Present work is aimed at development of experimental therapeutics for Cystic Fibrosis using advanced human cell culture models.

Dr. Scholte was contractor and group leader in two EU 6th FW projects aimed at correction of CFTR deficiency through gene and cell therapy, and steering committee member (animal models) of the EU CF concerted action (EUROCARECF). He was member of the Roadmap committee of the Dutch Respiratory society (NRS) and the organizing committee of the ECFS CF meetings in 2014 and 2015.


Group members, current.



Marta Stolarczyk Msc, Mieke Veltman Msc, Hamed Horati MD Msc



Collaborations, current


Dr Hettie Janssens MD (Erasmus MC CF center)

Dr Rabin Tirouvanziam (Tirouvanziam Lab Emory, Atlanta)

Dr Steve Stick MD (, Perth, Australia) 

Dr Ulrich Martin ( MHH Hannover, Germany MHH U.Martin), ERARE INSTINCT 

Dr Danuta Radzioch (McGill Montreal, Danuta Radzioch, PhD - Researchers) 

Dr Guido Veit (McGill Montreal Guido Veit)

Dr Robbert Rottier (Rottier lab ErasmusMC Ped Surgery) 




See Pubmed and Researchgate.


Contact Information

Visiting address
Dept. of Cell Biology
Erasmus MC
Faculty building
Room Ee 10-34
Wytemaweg 80
3015CN Rotterdam

phone +31-10-7043205 / 7043173
fax +31-10-7044743 

Mail address
Dept. of Cell Biology
Erasmus MC
Faculty building
PO Box 2040
3000 CA Rotterdam