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New gene involved in Parkinson’s and dementia with Lewy bodies

An international team led by Erasmus MC has discovered for the first time variants in a gene (termed LRP10) in patients with familial forms of Parkinson’s disease, Parkinson’s disease and dementia, and Dementia with Lewy bodies. The paper reporting this discovery is published in The Lancet Neurology.


‘This discovery opens a novel window on the molecular mechanisms of these common neurodegenerative diseases, and might pave the way to the identification of novel biomarkers and novel disease-modifying therapies’, says Prof. Vincenzo Bonifati from Erasmus MC Rotterdam, Department of Clinical Genetics.

Parkinson's disease and Dementia are common and devastating neurodegenerative diseases. Only symptomatic remedies are available, but not disease-modifying or curative therapies exist. Besides, the prevalence of these diseases is expected to increase in the future decades due to the aging of the populations of the world. These diseases pose therefore a huge medical and economic burden to the society.

Click here for the press release with links to more information on Prof. Bonifati and the publication in The Lancet.

Date published: 8 June 2018.

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