Pharmacy: Medication Optimization and Safety

Our research focuses on the optimalisation of pharmacotherapy from primary care to tertiary care settings. The main topics are:

• Prevention of (re)hospitalisations through the optimalisation of pharmacotherapy;
• Education to improve medication safety;
• Cardiovascular pharmacology: hypertension, including drug adherence and deprescribing;
• Cardiovascular side effects of anticancer therapy (“cardio-oncology”);
• Sex differences in side effects;
• Sustainability and efficient use of resources.

We aim to further establish our research line focusing on the above mentioned topics while being adaptive to novel developments in society and healthcare. We aim for collaboration within the pharmacy with the other research lines as well as other departments within the Erasmus MC to make our research multidisciplinary wherever possible. In addition, we aim to be adaptive to address novel research questions regarding medication optimization and safety as recently shown in the SWITCH study on vaccination strategies for COVID.

• Immunogenicity and Reactogenicity of Vaccine Boosters after Ad26.COV2.S Priming. 
  Sablerolles RSG, Rietdijk WJR, Goorhuis A, Postma DF, Visser LG, Geers D, Schmitz KS, Garcia Garrido HM, Koopmans MPG, Dalm VASH, Kootstra NA, Huckriede ALW, Lafeber M, van Baarle D, GeurtsvanKessel CH, de Vries RD, van der Kuy PHM; SWITCH Research Group.  N Engl J Med. 2022 Mar 10;386(10):951-963. doi: 10.1056/NEJMoa2116747. Epub 2022 Jan 19. PMID: 35045226; PMCID: PMC8796791.

• Real-time monitoring of drug laboratory test interactions: a proof of concept.
  van Balveren JA, Verboeket-van de Venne WPHG, Doggen CJM, Erdem-Eraslan L, de Graaf AJ, Krabbe JG, Musson REA, Oosterhuis WP, de Rijke YB, van der Sijs H, Tintu AN, Verheul RJ, Hoedemakers RMJ, Kusters R.Clin Chem Lab Med. 2021 Nov 9;60(2):235-242. doi: 10.1515/cclm-2021-0790. Print 2022 Jan 27.PMID: 34751523

• Better performance of medical students on pharmacotherapy knowledge and skills tests is associated with practising with e-learning program P-scribe
  Kalfsvel L, Versmissen J, van Doorn A, van den Broek W, van der Kuy H, van Rosse F. . Br J Clin Pharmacol. 2022 Mar;88(3):1334-1346. doi: 10.1111/bcp.15077. Epub 2021 Oct 5. PMID: 34505717.

• Dynamics of the QTc interval over a 24-h dose interval after start of intravenous ciprofloxacin or low-dose erythromycin administration in ICU patients.
  Berger FA, van Weteringen W, van der Sijs H, Hunfeld NGM, Bunge JJH, de Groot NMS, van den Bemt PMLA, van Gelder T.Pharmacol Res Perspect. 2021 Dec;9(6):e00865. doi: 10.1002/prp2.865.

• A cost-benefit analysis of hospital-wide medication reviews: a period prevalence study.
  Wilkes S, Zaal RJ, Abdulla A, Hunfeld NGM.  Int J Clin Pharm. 2022 Feb;44(1):138-145. doi: 10.1007/s11096-021-01323-1. Epub 2021 Sep 8. PMID: 34498214; PMCID: PMC8866269.

• The use of a clinical decision support tool to assess the risk of QT drug-drug interactions in community pharmacies.
  Berger FA, van der Sijs H, van Gelder T, van den Bemt PMLA. Ther Adv Drug Saf. 2021 Feb 24;12:2042098621996098. doi: 10.1177/2042098621996098. eCollection 2021.

• Pharmacogenomic response of low dose haloperidol in critically ill adults with delirium.
  Trogrlić Z, van der Jagt M, Osse RJ, Devlin JW, Nieboer D, Koch BCP, van Schaik RHN, Hunfeld NGM.J Crit Care. 2020 Jun;57:203-207. doi: 10.1016/j.jcrc.2020.03.001. Epub 2020 Mar 4.PMID: 32208328

• Clinical Applicability of Monitoring Antihypertensive Drug Levels in Blood. 
  Peeters LEJ, Feyz L, Boersma E, Daemen J, van Gelder T, Koch BCP, Versmissen J.Hypertension. 2020 Jul;76(1):80-86. doi: 10.1161/HYPERTENSIONAHA.120.15038. Epub 2020 May 18.PMID: 32418497

• Rosuvastatin use increases plasma fibrinolytic potential: a randomised clinical trial. 
  Schol-Gelok S, de Maat MPM, Biedermann JS, van Gelder T, Leebeek FWG, Lijfering WM, van der Meer FJM, Rijken DC,Versmissen J, Kruip MJHA.Br J Haematol. 2020 Apr 16. doi: 10.1111/bjh.16648. Online ahead of print.PMID: 32301122

• Acute calcium channel blocker withdrawal-induced cardiac arrest. 
  Peeters LEJ, den Uil CA, Feyz L, van den Bemt PMLA, Daemen J, Versmissen J.Neth J Med. 2019 Dec;77(9):341-343.PMID: 31814590 

• Pharmacokinetic and pharmacodynamic considerations in the treatment of the elderly patient with hypertension. 
  Peeters LEJ, Kester MP, Feyz L, Van Den Bemt PMLA, Koch BCP, Van Gelder T, Versmissen J.Expert Opin Drug Metab Toxicol. 2019 Apr;15(4):287-297. doi: 10.1080/17425255.2019.1588249. Epub 2019 Mar 16.

• Drug nonadherence is a common but often overlooked cause of hypertensive urgency and emergency at the emergency department. 
  Overgaauw N, Alsma J, Brink A, Hameli E, Bahmany S, Peeters LEJ, Van Den Meiracker AH, Schuit SCE, Koch BCP, Versmissen J.J Hypertens. 2019 May;37(5):1048-1057. doi: 10.1097/HJH.0000000000002005.PMID: 30480568

Principal Investigators

• 

  Prof. dr. P.H.M. (Hugo) van der Kuy

  Head of department of Hospital Pharmacy

• 

  Dr. L.E. (Loes) Visser

  Associate Professor

• 

  Dr. J. (Jorie) Versmissen

  Associate Professor

Project Leaders

• 

  Dr. F. (Floor) van Rosse

  Associate Professor

• 

  Dr. N.G.M. (Nicole) Hunfeld

  Assistant Professor

• 

  Dr. R.W.F. (Roelof) van Leeuwen

  Assistant Professor

• 

  Dr. I.H. (Heleen) van der Sijs

  Assistant Professor

• 

  Dr. R.J. (Rianne) Zaal

  Post-doc

Phd Students

• 

  S. (Samir) El Abdouni

  PhD student

• 

  Fauzia Chitanie

  PhD student

• 

  A. (Aniek) Dane

  PhD student

• 

  D. (Dimokrat) Hassan

  PhD student

• 

  M.L.A. (Magali) Heijkoop

  PhD student

• 

  M.A.M. (Marte) van Hylckama Vlieg

  PhD student

• 

  L.S. (Laura) Kalfsvel

  PhD student

• 

  R. (Ruben) Malmberg

  PhD student

• 

  N. (Narin) Martens-Akrawi

  PhD student

• 

  L.E.J. (Laura) Peeters

  PhD student

• 

  T.J.L. (Tim) Smeets

• 

  J.B. (Job) van Steenkiste

  PhD student

• 

  T.J.J. (Tom) Uyl, MD

  PhD student

• 

  L.K. (Lukas) van Vugt

  PhD student

• 

  S. (Sarah) Wilkes

  PhD student

• 

  M. (Michiel) Zietse

  PhD student