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Marion Ferren

Dr. M.A. (Marion) Ferren, PhD

Postdoctoral researcher

  • Focus area
  • Virology, Cross-reactive T-cell responses



Marion Ferren is a post-doctoral researcher at the Viroscience department of Erasmus MC with a focus on cross reactive T cell responses within Coronaviruses in Rory de Vries’ and Rik de Swart’s group. She obtained her PhD in 2021 under the supervision of Cyrille Mathieu in CIRI in Lyon (France) for her work on Paramyxoviruses central nervous system infection and fusion machinery. 

Field(s) of expertise

Paramyxoviruses, ex vivo models, central nervous infection, fusion machinery, T-cell response

Education and career

Research training and position:

  • 2022 – present: Postdoctoral researcher, Characterization of cross-reactive T-cells recognizing endemic and zoonotic coronaviruses, ERASMUS MC, Rotterdam, The Netherlands
  • 2018 – 2021: PhD Student, Physiopathology of central nervous infection with respiratory viruses, CIRI, Lyon, France
  • 2016 –2018: Staff Associate, Study of the mechanisms of entry and membrane fusion mediated by measles and parainfluenza virus, Columbia University Medical Center, New York, USA
  • 2014 –2015: Master 2, Development of an immunotherapy candidate for the treatment of chronic hepatitis B, Transgene, Lyon, France
  • 2013 – 2014: Master 1, Study of the formation of « DNA-contaning PML-NBs » during the herpes simplex virus type 1 infection, CNRS, Villeurbanne, France
  • 2012 and 2013: Bachelor, 2nd and 3rd year, Molecular and functional interactions of innate immunity receptors of the RIG-I family, CIRI, Lyon, France


  • 2021: PhD, Doctoral School BMIC (Integrative and Cellular Molecular Biology), University Claude Bernard Lyon 1, France
  • 2015: Master 2, UPMC (Paris VI) and ESTBB, Molecular and cellular biology, Lyon, France
  • 2014: Master 1, Ecole Pratique des Hautes Etudes (EPHE), Paris, France
  • 2013: Bachelor, ESTBB, UCLy, Lyon, France 


  1. Shyfrin SR, Ferren M, Perrin-Cocon L, Espi M, Charmetant X, Brailly M, Decimo D, Iampietro M, Canus Lola, Horvat B, Lotteau V, Vidalain PO, Thaunat O, Mathieu C. (2022) Hamster organotypic kidney culture model of early-stage SARS-CoV-2 infection highlights a two-step renal susceptibility. Journal of Tissue Engineering.

  2. Reynard O, Gonzalez C, Dumont C, Iampietro M, Ferren M, […] Matteo Porotto & Branka Horvat  B. (2022) Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nat. Commun.

  3. Ferren M, Favede V, Decimo D, Iampietro M, Lieberman NAP, Weickert J-L, Pelissier R, Mazelier M, Terrier O, Moscona A, Porotto M, Greninger AL, Messaddeq N, Horvat B & Mathieu C. (2021) Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection. Nat. Commun. 12, pp. 1–17.

  4. Mathieu C, Figueira TN, Decker AR, Ferren M, Bovier TF, Jurgens EM, Marcink TC, Moscona A & Porotto M. (2021) Measles fusion complexes from central nervous system clinical isolates: decreased interaction between hemagglutinin and fusion proteins. bioRxiv: 2021.06.18.449082

  5. Mathieu C, Bovier FT, Ferren M, Lieberman NAP, Predella C, Lalande A, Peddu V, Lin MJ, Addetia A, Patel A, Outlaw V, Corneo B, Dorrello NV, Briese T, Hardie D, Horvat B, Moscona A, Greninger AL & Porotto M. (2021) Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain. MBio 12(3)

  6. Iampietro M, Dumont C, Mathieu C, Spanier J, Robert J, Charpenay A, Dupichaud S, Dhondt KP, Aurine N, Pelissier R, Ferren M, Mély S, Gerlier D, Kalinke U & Horvat B. (2021) Activation of cGAS/STING pathway upon paramyxovirus infection. iScience 24: 102519

  7. Mathieu C, Ferren M, Harder O, Bovier FT, Marcink TC, Predella C, Angius F, Drew-Bear J, Dorrello NV, Greninger AL, Moscona A, Niewiesk S, Horvat B & Porotto M. (2021) Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo. Cell Mol Immunol 18: 1835–1837

  8. Ferren M, Horvat B, Gerlier D, Mathieu C. (2021) Type I interferon and selective permissiveness of central nervous system to measles virus infection. Medecine/Sciences. 37, 22–25

  9. Gaudino M, Aurine N, Dumont C, Fouret J, Ferren M, Mathieu C, Reynard O, Volchkov VE, Legras-Lachuer C, Georges-Courbot M-C & Horvat B. (2020) High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia. Emerg Infect Dis 26: 104–113

  10. Ferren M, Horvat B, Mathieu C. (2019) Measles encephalitis: Towards new therapeutics. Viruses. 11, 1017

  11. Porotto M, Ferren M, Chen Y-W, Siu Y, Makhsous N, Rima B, Briese T, Greninger AL, Snoeck H-W & Moscona A. (2019) Authentic modeling of human respiratory virus infection in human pluripotent stem cell-derived lung organoids. MBio 10(3)

  12. Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S & Porotto M. (2019) Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route. J Virol 93(8)

  13. Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M & Hardie D. (2019) Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain. J Virol 93(4)

  14. Iketani S*, Shean RC*, Ferren M*, Makhsous N, Aquino DB, Georges A des, Rima B, Mathieu C, Porotto M, Moscona A & Greninger AL. (2018) Viral entry properties required for fitness in humans are lost through rapid genomic change during viral isolation. MBio 9(4) (*co-first author)

Scholarships, grants, and awards

2022-2024 : EMBO Postdoctoral fellowship, ALT 977-2021