Dr. M.A. (Marion) Ferren, PhD

Research training and position:

• 2022 – present: Postdoctoral researcher, Characterization of cross-reactive T-cells recognizing endemic and zoonotic coronaviruses, ERASMUS MC, Rotterdam, The Netherlands
• 2018 – 2021: PhD Student, Physiopathology of central nervous infection with respiratory viruses, CIRI, Lyon, France
• 2016 –2018: Staff Associate, Study of the mechanisms of entry and membrane fusion mediated by measles and parainfluenza virus, Columbia University Medical Center, New York, USA
• 2014 –2015: Master 2, Development of an immunotherapy candidate for the treatment of chronic hepatitis B, Transgene, Lyon, France
• 2013 – 2014: Master 1, Study of the formation of « DNA-contaning PML-NBs » during the herpes simplex virus type 1 infection, CNRS, Villeurbanne, France
• 2012 and 2013: Bachelor, 2nd and 3rd year, Molecular and functional interactions of innate immunity receptors of the RIG-I family, CIRI, Lyon, France

Education: 

• 2021: PhD, Doctoral School BMIC (Integrative and Cellular Molecular Biology), University Claude Bernard Lyon 1, France
• 2015: Master 2, UPMC (Paris VI) and ESTBB, Molecular and cellular biology, Lyon, France
• 2014: Master 1, Ecole Pratique des Hautes Etudes (EPHE), Paris, France
• 2013: Bachelor, ESTBB, UCLy, Lyon, France 

1. Shyfrin SR, Ferren M, Perrin-Cocon L, Espi M, Charmetant X, Brailly M, Decimo D, Iampietro M, Canus Lola, Horvat B, Lotteau V, Vidalain PO, Thaunat O, Mathieu C. (2022) Hamster organotypic kidney culture model of early-stage SARS-CoV-2 infection highlights a two-step renal susceptibility. Journal of Tissue Engineering.
   
   
2. Reynard O, Gonzalez C, Dumont C, Iampietro M, Ferren M, […] Matteo Porotto & Branka Horvat  B. (2022) Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nat. Commun.
   
   
3. Ferren M, Favede V, Decimo D, Iampietro M, Lieberman NAP, Weickert J-L, Pelissier R, Mazelier M, Terrier O, Moscona A, Porotto M, Greninger AL, Messaddeq N, Horvat B & Mathieu C. (2021) Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection. Nat. Commun. 12, pp. 1–17.
   
   
4. Mathieu C, Figueira TN, Decker AR, Ferren M, Bovier TF, Jurgens EM, Marcink TC, Moscona A & Porotto M. (2021) Measles fusion complexes from central nervous system clinical isolates: decreased interaction between hemagglutinin and fusion proteins. bioRxiv: 2021.06.18.449082
   
   
5. Mathieu C, Bovier FT, Ferren M, Lieberman NAP, Predella C, Lalande A, Peddu V, Lin MJ, Addetia A, Patel A, Outlaw V, Corneo B, Dorrello NV, Briese T, Hardie D, Horvat B, Moscona A, Greninger AL & Porotto M. (2021) Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain. MBio 12(3)
   
   
6. Iampietro M, Dumont C, Mathieu C, Spanier J, Robert J, Charpenay A, Dupichaud S, Dhondt KP, Aurine N, Pelissier R, Ferren M, Mély S, Gerlier D, Kalinke U & Horvat B. (2021) Activation of cGAS/STING pathway upon paramyxovirus infection. iScience 24: 102519
   
   
7. Mathieu C, Ferren M, Harder O, Bovier FT, Marcink TC, Predella C, Angius F, Drew-Bear J, Dorrello NV, Greninger AL, Moscona A, Niewiesk S, Horvat B & Porotto M. (2021) Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo. Cell Mol Immunol 18: 1835–1837
   
   
8. Ferren M, Horvat B, Gerlier D, Mathieu C. (2021) Type I interferon and selective permissiveness of central nervous system to measles virus infection. Medecine/Sciences. 37, 22–25
   
   
9. Gaudino M, Aurine N, Dumont C, Fouret J, Ferren M, Mathieu C, Reynard O, Volchkov VE, Legras-Lachuer C, Georges-Courbot M-C & Horvat B. (2020) High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia. Emerg Infect Dis 26: 104–113
   
   
10. Ferren M, Horvat B, Mathieu C. (2019) Measles encephalitis: Towards new therapeutics. Viruses. 11, 1017
    
    
11. Porotto M, Ferren M, Chen Y-W, Siu Y, Makhsous N, Rima B, Briese T, Greninger AL, Snoeck H-W & Moscona A. (2019) Authentic modeling of human respiratory virus infection in human pluripotent stem cell-derived lung organoids. MBio 10(3)
    
    
12. Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S & Porotto M. (2019) Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route. J Virol 93(8)
    
    
13. Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M & Hardie D. (2019) Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain. J Virol 93(4)
    
    
14. Iketani S*, Shean RC*, Ferren M*, Makhsous N, Aquino DB, Georges A des, Rima B, Mathieu C, Porotto M, Moscona A & Greninger AL. (2018) Viral entry properties required for fitness in humans are lost through rapid genomic change during viral isolation. MBio 9(4) (*co-first author)