My research focuses on the improvement of perioperative care in children and the effect of anesthesia on the brain on the short and long term. Both database (retrospective and prospective) as well as clinical studies are being conducted, which ultimately aim to improve perioperative care in children. More specifically, to optimize neurodevelopmental outcome, which may be impacted by anesthesia. Hereto, I work together with various basic and clinical scientists of the Erasmus MC (Departments of Developmental and Experimental Psychology, and Social and Behavioral Sciences, Pediatrics, Pediatric Surgery, Neonatology, Pediatric Intensive Care, Experimental Cardiology and Radiology) and other academic medical centers around the World: a.o. Delft, Utrecht, Groningen, Antwerpen, Leuven, Genoa, Geneve, Melbourne, Sidney, Philadelphia and Boston.
Locally, I’m the PI of the PIANO-study, aiming to develop a new intraoperative non-invasive monitor device to detect brain ischaemia by HFR Doppler CUS (with Pediatric Surgery, Cardiology, Delft). Furthermore, I’m the PI of a pilot study to unlock the database of OR, NICU and PICU (with NICU and Delft), and I’m part of the “Sharing the Brain” research initiative on link long-term-outcome to perioperative factors to improve patient outcome after major surgery for (congenital) deformities and on an international study on perioperative brain monitoring in patients undergoing diaphragmatic hernia and esophageal atresia repair. Furthermore, I’m the PI of the national setup of the follow-up of the GAS-study: TRix-SAFETY-kids consortium. In this consortium participating the department of anesthesia of 8 UMCU’s and the department of Pediatric Intensive Care, Pediatric Surgery, Child Psychology, Pediatric Youth Psychiatry, and Radiology of the EMC.
Nationally, I’m working together with UMC Utrecht on the effect of artefacts in database studies and on the development of reference values for vital signs during anesthesia
Internationally, I’m involved in various international multicenter research projects (NECTARINE, MPOG, GAS-study, TREX-study, PeDi-Registry, isoelectric EEG events in infants) and one of the initiators of the Pediatric Perioperative Outcomes Group: Defining Core Outcomes for Pediatric Anesthesia and Perioperative Medicine.
Field(s) of expertise
Long term outcome
Education and career
A complete overview of publications can be found here:
Scholarships, grants, and awards
Website: Pediatric anesthesia