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Researcher

E.A.M. (Ellen) Schenk-Braat, PhD

Scientific Funding Navigator

  • Department
  • Urology
  • Focus area
  • National and European research and innovation funding programmes for LSH research, grant writing, project management, urological research
Contact   External Profile

About

Introduction

Current position

I provide strategic research advice to the Erasmus MC Department of Urology, guide researchers in the identification of (inter)national funding opportunities for their research and innovation activities, and support them in the writing of funding applications.

Professional experience

I am a research funding advisor for Life Sciences and Health research since 2002, and have been actively involved in the coordination of various (inter)national prostate cancer research consortia. I have a broad national and European network of research managers and administrators. I am vice-chair and co-founder of the Association for Research Managers and Administrators - The Netherlands, trainer for the European Association of Research Managers and Administrators and a former core group member of the COST Targeted Network BESTPRAC.

Field(s) of expertise

  • National and European research and innovation funding programs for LSH research, including Horizon 2020 and Horizon Europe.
  • Grant writing.
  • Project management.
  • Urological research.

Education and career

Career

  • April 2019 - now: Scientific Funding Navigator at Erasmus MC Department of Urology.
  • November 2016 - April 2019: Coordinator EU Funding at Erasmus MC Research Development Office.
  • August 2013 - November 2016: Head Grant Support Office at Erasmus MC Research Office Sophia.
  • September 2002 - August 2013: Scientific Project Manager at Erasmus MC Department of Urology.
  • April 2001 - September 2002: Group Leader Bio- and Immunochemistry Group at Pharming, Leiden.
  • February 2000 - April 2001: Project coordinator (ad interim) at Pharming, Leiden.
  • May 1999 - February 2000: Research Associate at Pharming, Leiden.

Education

  • 1994 - 1999: Phd student at University of Leiden, defence thesis "Relations between coagulation and fibrinolysis. A study on plasminogen activators" on 25 November 1999.
  • 1988 - 1994: Graduate student Biomedical Sciences at University of Leiden, graduated cum laude.

Publications

Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer.
Philip W Kantoff, Thomas J Schuetz, Brent A Blumenstein, L Michael Glode, David L Bilhartz, Michael Wyand, Kelledy Manson, Dennis L Panicali, Reiner Laus, Jeffrey Schlom, William L Dahut, Philip M Arlen, James L Gulley, Wayne R Godfrey. (2010). J Clin Oncol. 2010 Mar 1;28(7):1099-105.

Serum levels of arachidonic acid metabolites change during prostate cancer progression. 
Giovanny Rodríguez-Blanco, Peter C Burgers, Lennard J M Dekker, Jan J N Ijzermans, Mark F Wildhagen, Ellen A M Schenk-Braat, Chris H Bangma, Guido Jenster, Theo M Luider. (2014). Prostate. 2014 May;74(6):618-27.

Serum kynurenine/tryptophan ratio is not a potential marker for detecting prostate cancer.
Giovanny Rodríguez-Blanco, Peter C Burgers, Lennard J M Dekker 1, Mirella S Vredenbregt-van den Berg, Jan N M Ijzermans, Ellen A M Schenk-Braat, Guido Jenster, Theo M Luider. (2014). Clin Biochem. 2014 Sep;47(13-14):1347-8.

Preclinical safety assessment of Ad[I/PPT-E1A], a novel oncolytic adenovirus for prostate cancer.
Ellen Schenk, Magnus Essand, Robert Kraaij, Rachel Adamson, Norman J Maitland, Chris H Bangma. (2014).Hum Gene Ther Clin Dev. 2014 Mar;25(1):7-15.

In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus.
R E Adamson, A A Frazier, H Evans, K F Chambers, E Schenk, M Essand, R Birnie, R R Mitry, A Dhawan, N J Maitlan. (2012). Hum Gene Ther. 2012 Feb;23(2):218-30.

Adenovirus-derived vectors for prostate cancer gene therapy.
Jeroen de Vrij, Ralph A Willemsen, Leif Lindholm, Rob C Hoeben, GIANT Consortium; Chris H Bangma, Chris Barber, Jean-Paul Behr, Simon Briggs, Robert Carlisle, Wing-Shing Cheng, Iris J C Dautzenberg, Corrina de Ridder, Helena Dzojic, Patrick Erbacher, Magnus Essand, Kerry Fisher, April Frazier, Lindsay J Georgopoulos, Ian Jennings, Stefan Kochanek, Daniela Koppers-Lalic, Robert Kraaij, Florian Kreppel, Maria Magnusson, Norman Maitland, Patrick Neuberg, Regina Nugent, Manfred Ogris, Jean-Serge Remy, Michelle Scaife, Ellen Schenk-Braat, Erik Schooten, Len Seymour, Michael Slade, Pio Szyjanowicz, Thomas Totterman, Taco G Uil, Karel Ulbrich, Laura van der Weel, Wytske van Weerden, Ernst Wagner, Guy Zuber. (2010). Hum Gene Ther. 2010 Jul;21(7):795-805.

Clinical adenoviral gene therapy for prostate cancer.
Ellen Schenk, Magnus Essand, Chris H Bangma, GIANT FP6 Consortium; Chris Barber, Jean-Paul Behr, Simon Briggs, Robert Carlisle, Wing-Shing Cheng, Angelika Danielsson, Iris J C Dautzenberg, Helena Dzojic, Patrick Erbacher, Kerry Fisher, April Frazier, Lindsay J Georgopoulos, Rob Hoeben, Stefan Kochanek, Daniela Koppers-Lalic, Robert Kraaij, Florian Kreppel, Leif Lindholm, Maria Magnusson, Norman Maitland, Patrick Neuberg, Berith Nilsson, Manfred Ogris, Jean-Serge Remy, Michelle Scaife, Erik Schooten, Len Seymour, Thomas Totterman, Taco G Uil, Karel Ulbrich, Joke L M Veldhoven-Zweistra, Jeroen de Vrij, Wytske van Weerden, Ernst Wagner, Ralph Willemsen. (2010). Hum Gene Ther. 2010 Jul;21(7):807-13.

Gene transfer vectors targeted to human prostate cancer: do we need better preclinical testing systems?
Norman Maitland, Karen Chambers, Lindsay Georgopoulos, Martha Simpson-Holley, Regina Leadley, Helen Evans, Magnus Essand, Angelika Danielsson, Wytske van Weerden, Corrina de Ridder, Robert Kraaij, Chris H Bangma, GIANT FP6 Consortium. (2010). Hum Gene Ther. 2010 Jul;21(7):815-27.

Gene therapy in The Netherlands: highlights from the Low Countries.
Ellen A M Schenk-Braat, Leonie C M Kaptein, Marcella M Hallemeesch, Chris H Bangma, Rob C Hoeben. (2007). J Gene Med. 2007 Oct;9(10):895-903.

An inventory of shedding data from clinical gene therapy trials.
Ellen A M Schenk-Braat, Marjolein M K B van Mierlo, Gerard Wagemaker, Chris H Bangma, Leonie C M Kaptein. (2007). J Gene Med. 2007 Oct;9(10):910-21.

Gentherapie in Nederland, verleden, heden en toekomst.
E.A.M. Schenk-Braat, M.M.K.B. van Mierlo, G.A.P. Hospers, G. Wagemaker, C.H. Bangma en L.C.M. Kaptein. Ned Tijdschr Geneeskd 2007;151:1975-80.

Re: Five-year follow-up of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer. 
Ellen A M Schenk-Braat. (2007). Eur Urol. 2007 May;51(5):1442-3.

De zoektocht naar betere markers voor prostaatkanker dan prostaatspecifiek antigeen.
E.A.M. Schenk-Braat en C.H. Bangma. (2006). Ned Tijdschr Geneeskd 2006;150:1286-90.

Gene therapy in urology: strategies to translate theory into practice.
Chris H Bangma, Pierre Mongiat, Robert Kraaij, Ellen Schenk-Braat. (2005). BJU Int. 2005 Dec;96(8):1163-70.

Immunotherapy for superficial bladder cancer.
Ellen A M Schenk-Braat, Chris H Bangma. (2005). Cancer Immunol Immunother. 2005 May;54(5):414-23.

Identification of the epidermal growth factor-like domains of thrombomodulin essential for the acceleration of thrombin-mediated inactivation of single-chain urokinase-type plasminogen activator.
E A Schenk-Braat, J Morser, D C Rijken. (2001). Eur J Biochem. 2001 Nov;268(21):5562-9.

The inactivation of single-chain urokinase-type plasminogen activator by thrombin on cultured human endothelial cells.
E A Braat, A Collen, A F Jie, J M Grimbergen, D C Rijken. (2000). Biochim Biophys Acta. 2000 Sep 20;1497(3):351-8.

Urokinase-mediated fibrinolysis in the synovial fluid of rheumatoid arthritis patients may be affected by the inactivation of single chain urokinase type plasminogen activator by thrombin.
E A Braat, A F Jie, H K Ronday, B Beekman, D C Rijken. (2000). Ann Rheum Dis. 2000 Apr;59(4):315-8.

Fibrinolytic properties of activated FXII.
E A Braat, G Dooijewaard, D C Rijken.(1999). Eur J Biochem. 1999 Aug;263(3):904-11.

Inactivation of single-chain urokinase-type plasminogen activator by thrombin in human subjects.
E A Braat, M Levi, R Bos, F Haverkate, M R Lassen, M P de Maat, D C Rijken. (1999). J Lab Clin Med. 1999 Aug;134(2):161-7.

The inactivation of single-chain urokinase-type plasminogen activator by thrombin may provide an additional explanation for the antifibrinolytic effect of factor XI.
E A Braat, D C Rijken. (1999). Thromb Haemost. 1999 Apr;81(4):657.

The inactivation of single-chain urokinase-type plasminogen activator by thrombin in a plasma milieu: effect of thrombomodulin.
E A Braat, P Los, D C Rijken. (1998). Blood Coagul Fibrinolysis. 1998 Jul;9(5):419-27.

Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophages.
F Noorman, E A Braat, M Barrett-Bergshoeff, E Barbé, A van Leeuwen, J Lindeman, D C Rijken. J Leukoc Biol. 1997 Jan;61(1):63-72.

A sensitive bioimmunoassay for thrombin-cleaved two-chain urokinase-type plasminogen activator in human body fluids.
E A Braat, U Nauland, G Dooijewaard, D C Rijken. (1996). Thromb Haemost. 1996 Jun;75(6):908-14.

Degradation of tissue-type plasminogen activator by human monocyte-derived macrophages is mediated by the mannose receptor and by the low-density lipoprotein receptor-related protein.
F Noorman, E A Braat, D C Rijken. (1995). Blood. 1995 Nov 1;86(9):3421-7.

Hypokinesia in Parkinson's disease: influence of age, disease severity, and disease duration.
J J van Hilten, E A Braat, E A van der Velde, H A Middelkoop, J G van Dijk, G J Lighart, R A Roos. (1995). Mov Disord. 1995 Jul;10(4):424-32.

Ambulatory activity monitoring during sleep: an evaluation of internight and intrasubject variability in healthy persons aged 50-98 years.
J J van Hilten, E A Braat, E A van der Velde, H A Middelkoop, G A Kerkhof, H A Kamphuisen. (1993). Sleep. 1993 Feb;16(2):146-50.

Nocturnal activity and immobility across aging (50-98 years) in healthy persons.
J J van Hilten, H A Middelkoop, E A Braat, E A van der Velde, G A Kerkhof, G J Ligthart, A Wauquier, H A Kamphuisen. (1993). J Am Geriatr Soc. 1993 Aug;41(8):837-41.

Teaching activities

Trainer at the Early Stage Research Administrators and Managers (ESRAM) EARMA Masterclass.

Other positions

  • Vice-chair and co-founder of ARMA-NL (Association for Research Managers and Administrators - the Netherlands).
  • Core group member, Working Group 1 leader and Management Committee member of the COST Targeted Network BESTPRAC (2014 - 2019).