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Marc Raaijmakers

Raaijmakers Lab

The Raaijmakers laboratory is interested in the role of the bone marrow microenvironment in hematopoiesis and diseases of the hematopoietic system, particularly the initiation and evolution of pre-leukemic bone marrow disorders, such as bone marrow failure and myelodysplastic syndromes.

 

The studies aim to elucidate how specific cellular elements and molecular pathways within the bone marrow microenvironment contribute to disease pathogenesis and tumorigenesis in these conditions.

 

The laboratory strives to translate findings in pre-clinical models to human disease and explore therapeutic modalities aimed at targeting the bone marrow niche.

 

Research tools include transgenic disease and xenotransplant models, flow-cytometry co-culture systems, and state of the art molecular tools including loss of function shRNA screening.

 

Projects are performed in collaboration with the Erasmus Stem Cell Institute and the Center for Regenerative Medicine, Harvard Stem Cell Institute, U.S.A.