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Agenda. september 2018 tot 19-09-2019



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    Seminar Immunology

    “Functional genetic screens of regulatory DNA elements” by Reuven Agami, MD, Ph.D.

    The human genome carries genetic information in two distinct forms: Transcribed genes and regulatory DNA elements (rDEs). rDEs control the magnitude and pattern of gene expression, and are indispensable for organismal development and cellular homeostasis. Nevertheless, while large-scale functional genetic screens greatly advanced our knowledge in studying mammalian genes, such tools to study rDEs were lacking, impeding scientific progress. Interestingly, recent advance in genome editing technologies has not only expanded the available screening toolbox to interrogate genes, but also opened up novel opportunities in studying rDEs. We distinguish two types of rDEs: Transcriptional rDEs that recruit transcription factors to enhancers, and structural rDEs that maintain chromatin 3D structure to insulate transcriptional activities, a feature postulated to be essential for gene expression regulation by enhancers. In the seminar, I will describe proof-of-concepts experiments that we developed to target enhancers in a systematic way. We demonstrate its scalability and effectivity in identifying potential oncogenic and tumor-suppressive rDEs. These approaches can lead to better understand principles of transcription regulation and chromatin architecture in gene expression and cancer.

    Evenement

    27 september 2018
    16:00 - 17:00 uur

    Na-1202k

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    Seminar Immunology

    Title: to be announced, by Dirk Busch, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technishe Universität München

    Information: secretariaat.immunologie@erasmusmc.nl
    (contact Peter Katsikis)

    Evenement

    11 oktober 2018
    16:00 - 17:00 uur

    Na-1202k

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    Seminar Immunology

    Title: to be announced, by Benoit Stijlemans, Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium

    Information: secretariaat.immunologie@erasmusmc.nl
    (contact Pieter Leenen)

    Evenement

    18 oktober 2018
    16:00 - 17:00 uur

    Na-1202k

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    Seminar Immunology

    Title: to be announced, by Silvano Sozzani, Brescia, Italy

    Information: secretariaat.immunologie@erasmusmc.nl
    (contact Marjan Versnel)

    Evenement

    15 november 2018
    16:00 - 17:00 uur

    Na-1202k

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