target menu
... / Immunologie / Agenda
 

Agenda. november 2018 tot 14-11-2019



  •  

    Seminar Immunology

    "Multiple functions of plasmocytoid dedritic cells in autoimmunity' by Silvano Sozzani, Brescia, Italy

    Autoimmunity is characterized by the secretion of a complex cytokine milieu and by the accumulation of plasmacytoid dendritic cells (pDCs). pDCs are the main cells responsible for the sustained production of type I IFN that characterized autoimmune pathologies. The release of self-nucleic acids and the upregulation of circulating miRNAs represent relevant mechanisms of pDC activation in autoimmunity. However, pDCs may also produce other key proteins, such as Granzyme B (GrB). IL-21, a Th17-related cytokine upregulates the production and secretion of GrB. In vitro, pDCs promote keratinocyte killing by NK cells. In lupus erythematosus (LE) skin lesions, pDCs colocalize with NK cells and cytotoxic T cells at sites of epithelial damage. Therefore, pDCs exert multiple functions in autoimmunity and contribute to the onset of disease and tissue damage by multiple mechanisms.

    Evenement

    15 november 2018
    16:00 - 17:00 uur

    Na-1202k

  •  

    Seminar Immunology

    “Nucleic acids as a vaccine adjuvant and potential immunotherapeutic agent” by Ken J. Ishii, MD, Ph.D.

    Nucleic acids are an attractive molecule for both vaccine vector and immunotherapeutic agents. It is because 1) nucleic acids are easy to produce large amount relatively in a short time of period, and relatively simpler and cheaper than those produced as viral or bacterial vector or recombinant proteins. Synthetic DNA and RNA are also as an alternative immunotherapeutic for natural compounds such as cell wall extracts and purified components of bacteria and fungi. While DNA vaccines have been used in animals and human, capable of priming humoral and cellular immune responses to the encoded antigen (Ag), their ability to induce Ag-specific CD8+ T cell responses remain lower than expected. Among the strategies for improving DNA vaccine immunogenicity are booster vaccinations, alternate vaccine formulations, electroporation and genetic adjuvants, but few, such as extracellular vesicles (EVs), target natural Ag delivery systems. By focusing on CD63, a tetraspanin protein expressed on various cellular membranes, including EVs, we examined whether a DNA vaccine encoding an Ag fused to CD63 delivered into EVs would improve vaccine immunogenicity. Results suggest that CD63-fused antigen encoding DNA vaccination elicited secretion of Ag-loading extracellular vesicles that enhance Ag-specific CD8 T cells significantly better than the control groups. As a result, CD63-fused Ag-encoding DNA vaccines displayed promising outcome in prophylactic and therapeutic anti-tumor vaccination model in mice. I will present and discuss in detail about the results above. Clinical trials using immunostimulatory oligo- or cyclic di-nucleotides, particularly agonistic as well as non-agonistic ligands for Toll-like receptors (TLRs) and stimulator of interferon genes (STING), have revealed their therapeutic potential not only as vaccine adjuvants but also as mono-immuno-therapeutic agent such as an anti-tumor agent. I will overview the relevant R&D. Then I will present recent progress in our research and development for novel CpG ODN and/or STING ligand, which have been investigated as potential immunotherapeutic for cancer. We will discuss about new data obtained by various candidates for next generation CpG ODN and STING ligands, such as nanoparticle using non-agonistic Dectin-1 ligand .

    Evenement

    21 november 2018
    16:00 - 17:00 uur

    Na-1202k

  •  

    Seminar Immunology

    “T cell responses in infection and cancer: how post-transcriptional regulation defines immune responses” by Monika C. Wolkers Ph.D.

    T cells are critical to clear pathogens and malignant cells, and to protect us from recurring infections. Their instantaneous reactivity to pathogens upon reinfection is driven by the persistent expression of pre-formed cytokine mRNA. How aberrant cytokine production of pre-formed mRNA is prevented in the absence of infection, however, remains unresolved. Here, we show that post-transcriptional regulation through AU-rich elements (AREs) is key to block chronic production of cytokines in memory T cells. Binding of the RNA-binding protein ZFP36L2 to AREs represses the translation of pre-formed mRNA by impeding the recruitment of ribosomes. Upon T cell activation, the ZFP36L2-dependent translational block is rapidly relieved and pre-formed cytokine mRNA serves as ready-to-be-translated template, thus allowing swift recall responses to infection.
    To sustain T cell mediated cytokine production during infection, post-transcriptional regulation through AREs acquires a second function. In effector T cells, AREs control cytokine mRNA stability, which defines the magnitude and duration of T cell responses. However, T cells lose their capacity of cytokine production when continuously exposed to antigen, as in chronic infections or in tumors. We uncovered that AREs are critical in blocking the cytokine production. Genetic removel of AREs rectified the impaired T cell responses, demonstrating a critical role of AREs in the loss of effector function. In conclusion, we show that ARE-dependent post-transcriptional regulation dictates the magnitude and duration of cytokine production during all stages of T cell differentiation, and we present AREs as a new potential therapeutic target.

    Evenement

    6 december 2018
    16:00 - 17:00 uur

    Na-1202k

  •  

    Seminar Immunology

    Title: to be announced, by Dirk Busch, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technishe Universität München

    Information: secretariaat.immunologie@erasmusmc.nl
    (contact Peter Katsikis)

    Evenement

    10 januari 2019
    16:00 - 17:00 uur

    Na-1202k

  •  

    Seminar Immunology

    Title: to be announced, by Benoit Stijlemans, Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium

    Information: secretariaat.immunologie@erasmusmc.nl
    (contact Pieter Leenen)

    Evenement

    7 februari 2019
    16:00 - 17:00 uur

    Na-1202k

Helaas, uw zoekopdracht gaf geen resultaat voor deze categorie. Er zijn wel resultaten voor de andere categorie.