W.W.M. Pim Pijnappel
Associate Professor Molecular Stem Cell Biology
Dept Clinical Genetics , Erasmus MC
W.W.M. Pim Pijnappel, PhD
3015 CN Rotterdam
Pim Pijnappel obtained his MSc in Medical Biology at the Utrecht University (The Netherlands). In 1996, he obtained his PhD at the same university. He performed post-doctoral research at the EMBL (Heidelberg, Germany) and the Max Planck Institute (Dresden, Germany). In 2003, he became Head of the Netherlands Proteomics Biological Research Center at the UMC Utrecht. In 2012, he was appointed Head of Basal Research at the Center for Lysosomal and Metabolic Diseases at the Erasmus MC, Rotterdam.
Pim Pijnappel is interested in stem cells, gene expression and genome engineering. He pioneered identification of SET-domain protein complexes involved in epigenetic regulation of gene expression (Genes and Development, 2001). Using homologous recombination in E.coli (Red/ET recombination) he created versatile knock-in alleles in transgenic mice (Nature Biotechnology, 2003). His recent work identified the basal transcription factor TFIID as an important regulator of pluripotency in embryonic stem cells and during reprogramming to iPS cells (Nature, 2013). He recently moved to the Erasmus MC to the Center for Lysosomal and Metabolic Diseases. Here he applies advances in stem cell biology and genetic engineering to disease modeling and the development of novel therapies, with a focus on Pompe disease, a muscle degenerative disease.