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Arnab Ray Chaudhuri

DNA replication stress and genome instability

Our lab aims to understand the intricate structural and molecular mechanisms that link genome instability resulting from replication stress with tumorigenesis and chemoresistance. We use the genetic tractability of the mouse model organism with a combination of unique structural, biochemical and cell biological approaches to gain deeper insights into the mechanisms that that underlie the stabilization of the DNA replication machinery, thus resulting in genome stability.