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Hannes Lans

Mechanism and Regulation of Nucleotide Excision Repair

Nucleotide Excision Repair (NER) is a major DNA repair pathway that removes many divers helix-distorting lesions from DNA, such as those induced by UV-light and by several cancer therapeutics. We study how the mechanism and activity of NER is regulated within chromatin and in vivo, to understand how NER deficiency leads to disease and how this pathway can be exploited for cancer therapy. For our research, we use a range of cell biological, biochemical and genetic techniques and both mammalian cells as well as C. elegans as model systems.
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More information on NER and our group can be found on our website

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