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Joyce Lebbink

DNA Mismatch Repair

DNA mismatch repair (MMR) is responsible for correcting DNA replication errors and controls illegitimate DNA recombination. Non-functional MMR results in a mutator phenotype and in humans in an increased risk to develop cancer. MMR is a highly coordinated, multistep pathway in which a correct communication between the involved proteins on DNA is of crucial importance. Using in vitro reconstituted MMR reactions, we study this regulation in molecular detail.