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Publications

Publications

Traveling Rocky Roads: The Consequences of Transcription-Blocking DNA Lesions on RNA Polymerase II.
Steurer B, Marteijn JA.
J Mol Biol. 2016 Nov 13. pii: S0022-2836(16)30482- X. doi: 10.1016/j.jmb.2016.11.006.

Amplification of unscheduled DNA synthesis signal enables fluorescence-based single cell quantification of transcription-coupled nucleotide excision repair.
Wienholz F, Vermeulen W, Marteijn JA.
Nucleic Acids Res. 2017 Jan 13. pii: gkw1360. doi: 10.1093/nar/gkw1360.

Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage.
Tresini M, Marteijn JA, Vermeulen W.
RNA Biol. 2016;13(3):272-8.

Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair.
Marteijn JA, Hoeijmakers JH, Vermeulen W.
Mol Cell. 2015 Sep 17;59(6):885-6. doi: 10.1016/j.molcel.2015.09.007.

SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.
van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA.
Nat Commun. 2015 Jul 7;6:7499. doi: 10.1038/ncomms8499.

The core spliceosome as target and effector of non-canonical ATM signalling.
Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH,
Vermeulen W, Marteijn JA.
Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.

Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair.
Gourdin AM, van Cuijk L, Tresini M, Luijsterburg MS, Nigg AL, Giglia-Mari G, Houtsmuller AB, Vermeulen W, Marteijn JA.
DNA Repair (Amst). 2014 Dec;24:46-56. doi: 10.1016/j.dnarep.2014.09.013. Epub 2014 Oct 16.

Ubiquitin at work: the ubiquitous regulation of the damage recognition step of NER.
van Cuijk L, Vermeulen W, Marteijn JA.
Exp Cell Res. 2014 Nov 15;329(1):101-9. doi: 10.1016/j.yexcr.2014.07.018. Epub 2014 Jul 22.
Review.


Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription.
Aydin ÖZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H.
Nucleic Acids Res. 2014 Jul;42(13):8473-85. doi: 10.1093/nar/gku565. Epub 2014 Jul 2.

Understanding nucleotide excision repair and its roles in cancer and ageing.
Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH.
Nat Rev Mol Cell Biol. 2014 Jul;15(7):465-81. doi: 10.1038/nrm3822. Review.

Gearing up chromatin: A role for chromatin remodeling during the transcriptional restart upon DNA damage.
Mandemaker IK, Vermeulen W, Marteijn JA.
Nucleus. 2014 May-Jun;5(3):203- 10. doi: 10.4161/nucl.29085. Epub 2014 May 8. Review.

An immunoaffinity purification method for the proteomic analysis of ubiquitinated protein complexes.
Schwertman P, Bezstarosti K, Laffeber C, Vermeulen W, Demmers JA, Marteijn JA.
Anal Biochem. 2013 Sep 15;440(2):227-36. doi: 10.1016/j.ab.2013.05.020. Epub 2013 Jun 3.

Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage.
Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB,
Vermeulen W, Marteijn JA.
Mol Cell. 2013 Aug 22;51(4):469-79. doi: 10.1016/j.molcel.2013.08.007.

UVSSA and USP7, a new couple in transcription-coupled DNA repair.
Schwertman P, Vermeulen W, Marteijn JA.
Chromosoma. 2013 Aug;122(4):275-84. doi: 10.1007/s00412-013- 0420-2. Epub 2013 Jun 13.
Review.

Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b.
Bergink S, Theil AF, Toussaint W, De Cuyper IM, Kulu DI, Clapes T, van der Linden R, Demmers JA, Mul EP, van Alphen FP, Marteijn JA, van Gent T, Maas A,
Robin C, Philipsen S, Vermeulen W, Mitchell JR, Gutiérrez L.
Mol Cell Biol. 2013 Oct;33(19):3879-92. doi: 10.1128/MCB.05772-11. Epub 2013 Jul 29.

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.
Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ, Streicher W, Wikström M, Choudhary C, Houtsmuller AB, Marteijn JA, Bekker-Jensen S,
Mailand N.
J Cell Biol. 2013 Jun 10;201(6):797-807. doi: 10.1083/jcb.201212075.

UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway.
Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA.
J Cell Sci. 2013 May 1;126(Pt 9):1923-30. doi: 10.1242/jcs.118265. Epub 2013 Feb 27.

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling.
Smeenk G, Wiegant WW, Marteijn JA, Luijsterburg MS, Sroczynski N, Costelloe T, Romeijn RJ, Pastink A, Mailand N, Vermeulen W, van Attikum H.
J Cell Sci. 2013 Feb 15;126(Pt 4):889-903. doi: 10.1242/jcs.109413. Epub 2012 Dec 21.

Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
Theil AF, Nonnekens J, Steurer B, Mari PO, de Wit J, Lemaitre C, Marteijn JA, Raams A, Maas A, Vermeij M, Essers J, Hoeijmakers JH, Giglia-Mari G,
Vermeulen W.
PLoS Genet. 2013 Apr;9(4):e1003431. doi: 10.1371/journal.pgen.1003431. Epub 2013 Apr 18.

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.
Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, Hensbergen P, Deelder A, de Groot A, Matsumoto S, Sugasawa K, Thoma N,
Vermeulen W, Vrieling H, Mullenders L.
J Cell Biol. 2012 Oct 15;199(2):235-49. doi: 10.1083/jcb.201112132. Epub 2012 Oct 8.

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.
Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK.
Cell. 2012 Sep 14;150(6):1182-95. doi: 10.1016/j.cell.2012.08.005.

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA.
Nat Genet. 2012 May;44(5):598-602. doi: 10.1038/ng.2230.

ATP-dependent chromatin remodeling in the DNA-damage response.
Lans H, Marteijn JA, Vermeulen W.
Epigenetics Chromatin. 2012 Jan 30;5:4. doi: 10.1186/1756-8935- 5-4.

Involvement of global genome repair, transcription coupled repair, and
chromatin remodeling in UV DNA damage response changes during
development.
Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W.
PLoS Genet. 2010 May 6;6(5):e1000941. doi: 10.1371/journal.pgen.1000941.

The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13
interacting domains.
Marteijn JA, van der Meer LT, Smit JJ, Noordermeer SM, Wissink W, Jansen P,
Swarts HG, Hibbert RG, de Witte T, Sixma TK, Jansen JH, van der Reijden BA.
Leukemia. 2009 Aug;23(8):1480-9. doi: 10.1038/leu.2009.57. Epub 2009 Apr 2.

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1
and RNF8 and reveals a universal DNA damage response.
Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM,
Dantuma NP, Lukas J, Vermeulen W.
J Cell Biol. 2009 Sep 21;186(6):835-47. doi: 10.1083/jcb.200902150.

Ubiquitylation in normal and malignant hematopoiesis: novel therapeutic
targets.
Marteijn JA, Jansen JH, van der Reijden BA.
Leukemia. 2006 Sep;20(9):1511-8. Epub 2006 Jul 27.

The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary
myeloid progenitor cells.
Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de
Witte T, Löwenberg B, Jansen JH, van der Reijden BA.
Blood. 2005 Dec 15;106(13):4114-23. Epub 2005 Aug 23.

Human USP3 is a chromatin modifier required for S phase progression and
genome stability.
Nicassio F, Corrado N, Vissers JH, Areces LB, Bergink S, Marteijn JA, Geverts B,
Houtsmuller AB, Vermeulen W, Di Fiore PP, Citterio E.
Curr Biol. 2007 Nov 20;17(22):1972-7. Epub 2007 Nov 1.

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin
ligase Triad1.
Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de
Witte T, Jansen JH, Van der Reijden BA.
Blood. 2007 Nov 1;110(9):3128-35. Epub 2007 Jul 23.

Diminished proteasomal degradation results in accumulation of Gfi1 protein in
monocytes.
Marteijn JA, van der Meer LT, Van Emst L, de Witte T, Jansen JH, van der
Reijden BA.
Blood. 2007 Jan 1;109(1):100-8. Epub 2006 Aug 3.

Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-
induced mucosal barrier injury.
van t Land B, Blijlevens NM, Marteijn J, Timal S, Donnelly JP, de Witte TJ,M'Rabet L.
Leukemia. 2004 Feb;18(2):276-84.