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About Jurgen Marteijn

Jurgen MarteijnJurgen received his MSc in Biotechnology (cum laude) at the Wageningen University (Wageningen, The Netherlands), with a cellular/molecular biology specialization. He obtained his PhD degree from the Radboud University Medical Center (Nijmegen, The Netherlands) in 2007, on the role of the ubiquitin proteasome pathway during haematopoiesis.

Using the expertise acquired during my PhD on the PTM ubiquitin, I initiated an independent research line within the Genetics department to study this process during DNA-repair and DNA damage-associated signaling (Marteijn, JCB,2009 and van Cuijk, Nat.Com,2015).

Next, financed by my personal Veni and Horizon grants, I introduced quantitative proteomics in our department that resulted in the identification of UVSSA; a novel TCR factor, which is mutated in the UV-sensitive syndrome (Schwertman,Nat.Gen,2012). This finding formed the scientific basis for the NWO TOP and VIDI grants aimed to further dissect the regulation and molecular mechanism of Transcription-Coupled Repair (TCR) and to understand the severe clinical consequences associated with inherited TCR-defects. The current theme of my research group is how Nucleotide Excision Repair (NER) and the related DNA damage response (DDR) is regulated by post-translational modifications (PTMs) and protein-protein interactions in the context of chromatin.Research funded by my Erasmus MC fellowship, using a combination of my expertise in live-cell imaging and quantitative proteomics, has showed that chromatin remodeling is an essential process during the restart of transcription upon TCR (Dinant,Mol.Cel,2013) and revealed that the spliceosome is a key target of the DDR and defines a R-loop-dependent ATM activation by transcription-blocking lesions as an important event in the DNA damage response (Tresini,Nature,2015). These findings, together with the acquired expertise and international collaborations, put me in the unique position to answer the highly relevant questions in the TCR field, as described in this proposal, and build a frame work on how organisms cope with the severe consequences of DNA damage.