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Research Introduction

Research Introduction

TCRThe central theme of my research group is how Transcription-Coupled Repair (TCR) and the related DNA damage response (DDR) are regulated. TCR is a sub-pathway of Nucleotide Excision Repair (NER), which is an important DNA repair mechanism able to remove a broad range of different types of helix-distorting DNA lesions.

NER protects organisms against DNA damage-induced carcinogenesis and premature aging. Its significance is illustrated by the severe clinical consequences associated with inherited defects in NER, including the cancer-prone disease Xeroderma Pigmentosum (XP) and the premature ageing of Cockayne Syndrome (CS) patients. 

Using a combination of quantitative proteomics with state of the art live cell imaging approaches we study the function of NER in the living cell. Research questions include how the multi-step NER reaction is controlled by protein-protein interactions and posttranslational modifications, in particular by the ubiquitin proteasome system. Furthermore, we study how NER operates within chromatin and how NER is coordinated with other processes in the cell such as transcription.