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Recent Publications

Recent publications

Harnicek, D., Kampmann, E., Lauber, K., Hennel, R., Cardoso Martins, A.S., Guo, Y., Belka, C., Mörtl, S., Gallmeier, E., Kanaar, R., Mansmann, U., Lindner, L.H. and Issels, R.D.  (2016).  Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair.  Int. J. Cancer, doi: 10.1002/ijc.30070.

Naipal, K.A., Verkaik, N.S., Sánchez, H., van Deurzen, C.H., den Bakker, M.A., Hoeijmakers, J.H., Kanaar, R., Vreeswijk, M.P., Jager, A. and van Gent, D.C.  (2016).  Tumor slice culture system to assess drug response of primary breast cancer.  BMC Cancer 16, 78.

Issels, R., Kampmann, E., Kanaar, R. and Lindner, L.H.  (2016).  Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application.  Int. J. Hyperthermia Jan 24, 1-7.

Tham, K.C., Kanaar, R. and Lebbink, J.H. (2015).  Mismatch repair and homeologous recombination.  DNA Repair 38, 75-83.

Ameziane, N., May, P., Haitjema, A., Van de Vrugt, H.J., Van Rossum-Fikkert, S.E., Ristic, D., Williams, G.J., Balk, J., Rockx, D., Li, H., Rooimans, M.A., Oostra, A.B., Velleuer, E., Dietrich, R., Bleijerveld, O.B., Altelaar, A.F.M., Meijers-Heijboer, H., Joenje, H., Glusman, G., Roach, J., Hood, L., Galas, D., Wyman, C., Balling, R., den Dunnen, J., De Winter, J.P., Kanaar, R., Gelinas, R. and Dorsman, J.C.  (2015).  A novel Fanconi anemia subtype associated with a dominant-negative mutation in RAD51.  Nature Comm. 6, 8829.

Ramnath, N.W., Hawinkels, L.J., van Heijningen, P.M., te Riet, L., Paauwe, M., Kanaar, R., ten Dijke, P. and Essers, J.  (2015).  Fibulin-4 deficiency results in enhanced TGF-β signaling in aortic smooth muscle cells and increased TGF-β2 secretion.  Sci. Rep. 5, 16872.

Naipal, K.A., Raams, A., Bruens, S.T., Verkaik, N.S., Jaspers, N.G., Hoeijmakers, J.H., van Leenders, A., Pothof, J., Kanaar, R., Boormans, J. and van Gent, D.C.  (2015).  Attenuated XPC expression does not associate with impaired DNA repair in bladder cancer.  PLoS One 10, e0126029.

Braks, J.A., Spiegelberg. L., Koljenovic, S., Ridwan, Y., Keereweer, S., Kanaar, R., Wolvius, E.B. and Essers, J.  (2015).  Optical imaging of tumor response to hyperbaric oxygen treatment and irradiation in an orthotopic mouse model of head and neck squamous cell carcinoma.  Mol. Imaging Biol. 7, 633-642.

Reuter, M., Zelensky, A., Smal, I., Meijering, E., van Cappellen, W.A., de Gruiter, M.H., van Belle, G.J., van Royen, M.E., Houtsmuller, A.B., Essers, J., Kanaar, R. and Wyman, C.  (2014).  BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells.  J. Cell Biol. 207, 599-613.


Uringa, E.J., Baldeyron, C., Odijk, H., Wassenaar, E., van Cappellen, W.A., Maas, A., Hoeijmakers, J.H., Baarends, W.M., Kanaar, R. and Essers, J.  (2015).  A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.  DNA Repair 25, 27-40.

Berghauser Pont, L.M.E., Kloezeman, J.J., Naipal, K., van den Bent, M., van Gent, D.C., Dirven, C.M.F., Kanaar, R., Lamfers, M.L. and Leenstra, S.  (2015).  DNA damage response and anti-apoptotic proteins are predictors of histone deacetylase inhibitors-mediated radiosensitization of glioblastomas.  Cancer Res. 28, 525-535.

Zelensky, A., Kanaar, R. and Wyman, C.  (2014).  Mediators of homologous DNA pairing.  Cold Spring Harb. Perspect. Biol. 6, a016451.

Ramnath, N.W.M., van de Luijtgaarden, K.M., van der Pluijm, I., van Nimwegen, M., van Heijningen, P., Swagemakers, S., van Thiel, B., Ridwan, R., van Vliet N., Vermeij, M., Hawinkels, L., de Munck, A., Dzyubachyk, O., Meijering, E., van der Spek, P., Rottier, R., Hendriks, R.W., Kanaar, R., Rouwet, E.V., Kleinjan, A. and Essers, J.  (2014).  Extracellular matrix defects in aneurysmal Fibulin-4 deficient mice predispose to lung emphysema.  PloS One 9, e106054.

Naipal, K.A., Verkaik, N.S., Ameziane, N., van Deurzen, C.H., Ter Brugge, P., Meijers, M., Sieuwerts, A.M., Martens, J., O'Connor, M.J., Vrieling, H., Hoeijmakers, J.H., Jonkers, J., Kanaar, R., de Winter, J., Vreeswijk, M., Jager, A. and van Gent, D.C.  (2014).  Functional ex vivo assay to select homologus recombination deficient breast tumors for PARP inhibitor treatment.  Clin. Cancer Res. 20, 4816-4826.

Kuzniar, A. and Kanaar, R.  (2014).  PIQMIe: a web server for semi-quantitative proteomics data management and analysis.  Nucleic Acids Res. 42, W100-106.

Carvalho, J.F. and Kanaar, R.  (2014).  Targeting homologous recombination-mediated DNA repair in cancer. Expert Opin. Ther. Targets 18, 427-458.

Shima, H., Suzuki, H., Sun, J., Kono, K., Shi, L., Kinomura, A., Horikoshi, Y., Ikura, T., Ikura, M., Kanaar, R., Igarashi, K., Saitoh, H., Kurumizaka, H. and Tashiro, S.  (2014).  Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage.  J. Cell Sci. 126, 5284-5292.