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Nitika Taneja

Chromatin Remodeling and Replication

Our lab aims to understand the mechanistic link between chromatin remodeling pathways and the stability of DNA replication machinery to proper chromatin organization and concomitant genome stability. Through our research aimed at targeting chromatin remodelers, we will obtain a mechanistic understanding of the cellular processes that render cells sensitive or resistant to commonly used chemotherapeutic treatments. We study chromatin remodeling and DNA replication using multiple model systems that include cultured human cells, mouse tumor models, 3D-organoids and fruit flies. We genetically manipulate and study these model systems using a combination of high-throughput cell biology, genomic and biochemistry techniques to discover the underlying mechanisms in normal cells that counteract replicative stress and thus avert tumorigenesis.