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Dik van Gent

DNA Repair Research for Optimized Tumor Treatment

 
The group studies various aspects of DNA double strand break repair, with an emphasis on a better understanding of DNA damaging anti-tumor therapies and how these therapies can be optimized for specific tumors. For this purpose we have developed novel technology to allow direct investigation of DNA damage responses in tumor tissue slices derived from fresh clinical samples. We also carry out more mechanistic studies, which currently concentrate mainly on DNA repair after radionuclide therapy and PARP inhibitor resistance mechanisms in BRCA-mutated tumors.