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Claire Wyman

Molecular nanomachinery of DNA break repair

We aim to understand fundamental principles that determine complex biological processes. We currently focus on the process of double-strand DNA break repair in relation to genomic (in)stability, carcinogenesis and radio- and chemotherapy. We develop and apply new methods from single molecule imaging to live cell microscopy for quantitative analysis of detailed molecular function. Although our focus is fundamental knowledge, the mechanistic information we reveal are needed both to understand molecular causes that promote tumor formation, and to design of strategies specifically sensitizing rapidly dividing cells to anti-cancer treatments based on DSB induction.