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Joost Gribnau

Joost Gribnau graduated in biochemistry at the university of Leiden, and received his PhD in the department of Cellbiology and Genetics at the Erasmus University Rotterdam (1999) where he studied the regulation of beta globin gene expression and chromatin structure. His postdoctoral training was at the Whitehead Institute for Biomedical Research / MIT (Cambridge, USA) in the laboratory of Prof. R. Jaenisch. He studied the role of replication timing and DNA methylation in genomic imprinting and X inactivation. He also developed a system, which allows monitoring of Xist RNA in living cells.

In 2004 he started his own research group at the department of Cellbiology at the Erasmus MC and recently moved to the department of Reproduction and Development. He is recipient of 2004 VIDI and HFSP CDA grants. His main interests are X inactivation and genomic imprinting. His group is studying the role of Xist RNA and Xist RNA associated proteins at different stages of the X inactivation process. In 2010 he received a VICI grant.


Barakat TS, Jonkers I, Monkhorst K, Gribnau J (2010)
X-changing information on X inactivation
Exp Cell Res 316(5):679-687

Jonkers I, Barakat TS, Achame EM, Monkhorst K, Kenter A, Rentmeester E, Grosveld F, Grootegoed JA, Gribnau J (2009)
RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation
Cell 139(5):999-1011

Monkhorst K, de Hoon B, Jonkers I, Mulugeta Achame E, Monkhorst W, Hoogerbrugge J, Rentmeester E, Westerhoff HV, Grosveld F, Grootegoed JA, Gribnau J (2009)
The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties
PLoS One 4(5):e5616

Monkhorst, K., Jonkers, I., Rentmeester, E., Grosveld, F., and Gribnau, J. (2008)
X inactivation counting and choice is a stochastic process: evidence for involvement of an X-linked activator
Cell 132, 410-421

Wutz, A., and Gribnau, J. (2007)
X inactivation Xplained
Curr Opin Genet Dev 17, 387-393

J. Gribnau, Luikenhuis S, Hochedlinger K, Monkhorst K and R. Jaenisch. 2005
X chromosome choice occurs independently of asynchronous replication timing
J Cell Biol. 168:365-73

N. Geijsen, M. Horoschak, K. Kim, J. Gribnau, K. Eggan and G. Daley. 2004
Derivation of embryonic germ cells and male gametes from embryonic stem cells
Nature 427:148-54

J. Gribnau, K. Hata, K. Hochedlinger, E. Li and R. Jaenisch. 2003
Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential sub-nuclear localization
Genes & Development. 17:759-73