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3D reconstruction of coronary arteries

3D reconstruction of coronary arteries including vessel wall

Investigators: Jolanda Wentzel, Frank Gijsen, Annette Kok, Erik Jan Postema

Introduction

Shear stress of the blood at the vessel wall is an important biomechanical parameter in the localization and progression of atherosclerosis. Wall stress, the stress inside the vessel wall, determines the risk of plaque rupture. In order to assess the biomechanical parameters, shear stress and wall stress, using finite element modeling a 3D description of the lumen and vessel wall, including the composition, is required.

  

3D reconstruction

We developed a framework in which we can combine the accurate lumen and wall information from intravascular ultrasound (IVUS) together with the 3D centerline shape acquired from coronary computed tomography (CTA). The 2D lumen and wall contours from IVUS are placed on the 3D CTA centerline by comparing landmarks such as bifurcations and calcifications on the IVUS images and cross-sectional images of CTA taking correct rotation into account. The framework allows extension to other IVUS derived intravascular imaging techniques, including virtual histology and the combination of IVUS and near infrared spectroscopy (NIRS-IVUS), but also light based intravascular imaging techniques such as optical coherence tomography (OCT) can be used. Curently, we are developing methods to add both plaque composition and side branches to the 3D reconstructions of the coronary arteries.

NIR-IVUS fused with MSCT

NIRS-IVUS fused in CT: 3D CT dataset of the heart fused with the NIRS-IVUS derived geometry of the lumen on which the calculated WSS values are depicted